Virtual population model predicts and stops kidney damage in black Americans

PHILADELPHIA (April 2, 2022) – Researchers have successfully used a virtual population to replicate a clinical trial that examined kidney damage in black Americans, according to a new study from the University of Mississippi Medical Center at Jackson. John S. Clemmer, PhD, physiologist and lead author of the study, said his team model used a calcium channel blocker to predict kidney damage. They were also able to simulate stopping the damage by adding drug treatment (angiotensin inhibitor) and reducing salt intake. Simulated treatments also improved the heart size of virtual patients. The research will be presented in person at the American Physiological Society (APS) Annual Meeting at Experimental Biology 2022 in Philadelphia.

In this study, researchers used an existing long-term clinical trial to determine the effect of calcium channel blockers in black patients with poor kidney function. Next, they deployed a physiological model to simulate clinical trials and predict outcomes. The hope is that “these findings and this technique could be used to predict the potential risks of certain therapies in vulnerable populations,” Clemmer said.

According to the National Kidney Foundation, black people in the United States, among other minorities, “may be at increased risk for kidney disease.” In fact, blacks are more than three times more likely than their white counterparts to have kidney failure. Additionally, black people have “significantly higher rates of high blood pressure, diabetes, obesity, and heart disease, all of which increase the risk of kidney disease,” the foundation reported.

NOTE TO EDITORS: To schedule an interview with a member of the research team and/or to request abstract R603, “Modeling the Progression of Hypertensive Kidney Disease in African Americans”, please contact APS Media Relations or call 301.634.7314. Find other research highlights in the APS Newsroom.

About Experimental Biology 2022

Experimental Biology is the annual meeting of five societies that explores the latest research in physiology, anatomy, biochemistry and molecular biology, investigative pathology, and pharmacology. With a mission to share the latest scientific concepts and research findings shaping clinical advances, the meeting provides an unprecedented opportunity for global exchange between scientists who represent dozens of scientific fields, from laboratory to translational research. to clinical research.

About the American Physiological Society

Physiology is a broad area of ​​scientific research that focuses on how molecules, cells, tissues, and organs function in health and disease. The American Physiological Society connects a global, multidisciplinary community of more than 10,000 biomedical scientists and educators in its mission to advance scientific discovery, understand life, and improve health. The Society encourages collaboration and highlights scientific discoveries through its 16 scholarly journals and programming that support researchers and educators in their work.

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