long term – Vet Clin Path Journal http://vetclinpathjournal.org/ Wed, 09 Mar 2022 07:31:04 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://vetclinpathjournal.org/wp-content/uploads/2021/05/cropped-icon-32x32.png long term – Vet Clin Path Journal http://vetclinpathjournal.org/ 32 32 15 medical societies establish seven guiding principles for the perioperative treatment of acute pain https://vetclinpathjournal.org/15-medical-societies-establish-seven-guiding-principles-for-the-perioperative-treatment-of-acute-pain/ Wed, 09 Mar 2022 02:56:00 +0000 https://vetclinpathjournal.org/15-medical-societies-establish-seven-guiding-principles-for-the-perioperative-treatment-of-acute-pain/

The American Society of Anesthesiologists (ASA) and 14 major medical specialty organizations have established seven guiding principles to best address the perioperative management of acute pain in complex surgical patients. The principles were established at a historic Pain Summit, the second of its kind, hosted by the ASA.

Every surgical patient deserves adequate pain relief that aims to prevent opioid addiction, chronic pain, and other negative outcomes, but achieving this may be more difficult in certain patient populations. The new principles have been created to build on an original set established last year at our first Pain Summit, but are aimed specifically at patients undergoing surgery with chronic pain, those taking opioids before surgery and to those with substance use disorders. The new principles give the perioperative care team more guidance in caring for these particularly complex patients.”

Randall M. Clark, MD, FASA, ASA President

In February 2021, the ASA convened 14 medical specialty organizations for a Virtual Pain Summit to collaborate on a resource for acute surgical pain care. Participating organizations reached consensus on seven fundamental principles of perioperative management of acute pain, published in Regional anesthesia and pain medicine. To build on the best practices and knowledge shared at the first pain summit, a second virtual summit was held on February 26, 2022 to establish guiding principles for treating complex surgical patients.

The seven new principles, which will be developed into a resource for clinicians and other members of the healthcare team, recommend:

  1. If clinicians identify a positive screen for substance use pre-operatively, a more detailed assessment tool should be used to stratify patients’ risks for further support or referral for treatment, as appropriate.
  2. During a preoperative assessment, if a patient is identified as having chronic pain, opioid tolerance, or a substance use disorder, clinicians should coordinate with the patient’s care team, including including consultation with a specialist in pain medicine, behavioral health or addiction.
  3. For patients on long-term opioid therapy preoperatively, clinicians should coordinate with the patient’s prescribing clinician and continue the baseline opioid dose during the perioperative period with supplemental analgesia as needed for acute postoperative pain.
  4. Clinicians should work with patients who have opioid tolerance on an individualized postoperative opioid reduction plan, in coordination with the clinician prescribing long-term opioids, with the goal of returning to or below the preoperative dose as soon as possible.
  5. For patients who were prescribed opioids at discharge from surgery, clinicians should educate them and their caregivers about the risks, signs, and management of opioid-induced respiratory depression; that they should avoid the concomitant consumption of drugs with a sedative effect and alcohol when taking opioids; and when to call for emergency help.
  6. For patients identified as being at significant risk for opioid-related adverse events or severe uncontrolled perioperative pain, clinicians should consult with a pain specialist or anesthetist before surgery.
  7. For patients identified as benefiting from an additional consultation with a pain medicine, behavioral health, or addictions specialist, clinicians should use telehealth options if in-person consultation is not available.

In addition to the ASA, participating medical organizations include:

  • American Academy of Orthopedic Surgeons
  • American Academy of Otolaryngology-Head and Neck Surgery
  • American Association of Neurological Surgeons
  • American Association of Oral and Maxillofacial Surgeons
  • American College of Obstetricians and Gynecologists
  • American College of Surgeons
  • American Hospital Association
  • American Medical Association
  • American Society for Addiction Medicine
  • American Society of Breast Surgeons
  • American Society of Plastic Surgeons
  • American Society of Regional Anesthesia and Pain Medicine
  • American Urological Association
  • Society of Thoracic Surgeons

“The next step for this consortium and multi-company effort is to establish how we can help institutions implement both sets of guiding principles into their practices,” Dr. Clark said.


American Society of Anesthesiologists

American Cancer Society CEO issues call to action on genitourinary cancer disparities https://vetclinpathjournal.org/american-cancer-society-ceo-issues-call-to-action-on-genitourinary-cancer-disparities/ Sat, 19 Feb 2022 02:11:46 +0000 https://vetclinpathjournal.org/american-cancer-society-ceo-issues-call-to-action-on-genitourinary-cancer-disparities/

February 18, 2022

4 minute read



Knudsen KE. A way forward, a call to action: Addressing trends and disparities in genitourinary cancers. Presented at: ASCO Genitourinary Cancer Symposium; February 17-19, 2022; San Francisco.

Disclosures: Knudsen does not report any relevant financial information.

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SAN FRANCISCO — Tackling disparities in genitourinary cancers requires more research into changing risk factors and immediate actions aimed at prevention, Karen E. Knudsen, PhD, MBA, said at the ASCO Symposium on Genitourinary Cancers.

Knudsen – who last year became CEO of the American Cancer Society and its advocacy affiliate, American Cancer Society Cancer Action Network – used her keynote address at the symposium to highlight trends in incidence and genitourinary cancer mortality in the United States, as well as priorities for the field.

More than 3.5 million cancer deaths have been averted since 1991 following a “doubling of investment in cancer research,” Knudsen said.

“Still, we are not entirely satisfied,” she added. “We know, even as we celebrate this 32% reduction in cancer mortality, that progress has not benefited everyone. … We still have a lot of work to do.

Karen E. Knudsen, MBA, Ph.D.

Karen E. Knudsen

Known sources of racial disparities in cancer outcomes include lack of transportation, need for housing near cancer centers, lack of health and digital literacy, hesitancy to enroll in clinical trials and unconscious bias among providers and health systems.

“Let’s take those truths that we know exist and go beyond implementation strategies,” she said.

Genitourinary cancers, which account for more than 20% of new cancer cases each year, pose a significant problem, Knudsen said. Prostate and bladder cancers alone are responsible for 14.4% of all cancer deaths in men, she added.

Bladder cancer

Disparities in bladder cancer include four times higher incidence and three to four times higher mortality in men than in women. This pattern is distinct from lung cancer profiles, which show gender convergence, Knudsen said.

Meanwhile, death rates have steadily declined among black men while remaining higher among white men, again different from lung cancer trends.

“From research, we can ask ourselves in terms of risk factors, is there something we’re missing?” Knudsen said. “We also know that there is currently no screening method for people at average risk. We are also watching the development of tests for the early detection of several cancers, and we look forward to strong evidence that these tests actually show clinical benefit.

Strategies that could be implemented immediately include increased smoking cessation efforts, she said.

kidney cancer

The long-term increase in the incidence of kidney cancer — mostly from diagnoses at the localized stage — can be attributed in part to the incidental detection of asymptomatic tumors through increased medical imaging, Knudsen said.

“There is a slow but steady increase by gender [and] demographic, so different from what we’ve seen with bladder cancer,” she said. “We suggest that the call to action here, in fact, is prevention, because approximately half of kidney cancers that are reported now can be prevented by eliminating important risk factors for this disease. [These] include being overweight and smoking.

Kidney cancer mortality, which has been declining since the mid-1990s, has remained relatively stable among black men despite their higher incidence rate, while increasing among both men and women.

Research should seek to identify the basis for the discrepancy in incidence and mortality among black men and lower incidence among Asian/Pacific Islanders, as well as additional risk factors, Knudsen said.

She suggested promoting healthy lifestyles and prevention strategies as immediate steps that can be taken.

Prostate cancer

Prostate cancer incidence dropped significantly following US Preventive Services Task Force recommendation against screening; however, it remains 73% higher among black men than among white men. The reasons for this difference remain unknown, Knudsen said.

Testing rates among black men and white men in the United States are roughly equal but remarkably low, she said.

“Although they are fair, I don’t think we can celebrate a third of the men [undergoing] prostate cancer screening,” Knudsen said.

A slight increase in the incidence of localized stage and regional stage disease occurred after readjustment of screening guidelines, but the most dramatic change was seen in distant stage disease, which increased by 4 % to 6% per year since 2011.

“For us at the American Cancer Society, this is a call to arms,” ​​Knudsen said.

The steep declines in death rates in all groups since the mid-1990s are starting to flatten out, which may indicate testing saturation or a need for new therapeutic strategies, Knudsen said.

His calls to action included refining screening and stepping up the search for new therapeutic strategies.

A review of regional differences in prostate cancer incidence and mortality in the United States revealed striking variations that should be investigated, Knudsen said. For example, incidence and mortality rates appeared to be balanced in Florida, while California had the lowest incidence but the highest mortality. In the Carolinas, black men had significantly higher death rates than white men, while in New York and Texas, black men and white men had equal outcomes.

“We know part of that is access to care,” Knudsen said.

Knudsen suggested the adoption of evidence-based screening to reverse the diagnostic shift to more advanced disease. She also highlighted the need for efforts to address disparities in outcomes by region and demographic group, the underuse of germline testing in localized disease, and variations in clinical trial uptake.

Testicular cancer

The incidence of testicular cancer increased for all subgroups, but Knudsen described the increase in incidence and mortality among Hispanics as alarming.

“There’s a big call to action here too, to increase testing, to increase awareness and to really understand the risk factors,” she said.

Regional variations have been identified across the country. For example, Louisiana has balanced testicular cancer incidence and mortality rates, while Arizona has the lowest incidence and highest mortality.

Understanding the basis for these variations should be a research priority, Knudsen said. “But right now we can increase awareness and we can increase uptake of testing,” she said. “I will flag to you, as CEO of the American Cancer Society, now that we have come to this realization, we will be part of this solution in states that have this high incidence.”

The references:

]]> LDH Appoints Melinda ‘Mendy’ Richard as Assistant Secretary of the Office of Aging and Adult Services https://vetclinpathjournal.org/ldh-appoints-melinda-mendy-richard-as-assistant-secretary-of-the-office-of-aging-and-adult-services/ Wed, 16 Feb 2022 00:16:21 +0000 https://vetclinpathjournal.org/ldh-appoints-melinda-mendy-richard-as-assistant-secretary-of-the-office-of-aging-and-adult-services/

The Louisiana Department of Health (LDH) today announced the appointment of Melinda “Mendy” Richard as the Associate Secretary of the Office of the Department of Aging and Adult Services (OAAS). Richard most recently served as Deputy Assistant Secretary of the Office of Community Preparedness and Health Protection at the Office of Public Health (OPH).

Richard will begin his new role as Assistant Secretary on Monday, February 28. She will take over from Acting Assistant Secretary Elizabeth Adkins, who will serve as the OAAS Deputy Assistant Secretary.

OAAS was created within the Department of Health as a health care reform initiative, bringing together all long-term care programs that serve elderly residents and people with disabilities at the age adult.

Richard joined LDH in 2016 after more than 20 years of public service at Louisiana State University’s Pennington Biomedical Research Center, Department of Public Safety – Louisiana State Police Crime Lab, and Division of Administration. She graduated from Louisiana State University and LSU Health Sciences Center in New Orleans with a Bachelor of Science in Medical Technology. Richard is a Fellow of the American Society for Quality and a Certified Clinical Laboratory Scientist with the American Society for Clinical Pathology. She is also a Lean Six Sigma Master Black Belt.

WSU Vets Make Young Puppy’s Second Birthday Possible – WSU Insider https://vetclinpathjournal.org/wsu-vets-make-young-puppys-second-birthday-possible-wsu-insider/ Fri, 04 Feb 2022 14:10:43 +0000 https://vetclinpathjournal.org/wsu-vets-make-young-puppys-second-birthday-possible-wsu-insider/

Cami Anderson and her family spared no expense for their young pup, Holli’s second birthday.

There were matching party hats for Holli and her best friend, Rosko, the family’s 13-year-old Labrador mix; tons of new toys; and even a Starbucks puppuccino.

It was a day the Andersons doubt they would have seen without expert care at Washington State University Veterinary Teaching Hospital, where less than two months earlier Holli had suffered a life-saving surgery to remove a life-threatening cyst on his brain. Recovery has had its tough and scary moments, but the family is grateful for every day spent with their beloved dog.

“Holli seems to be getting better every day,” Cami said. “Every day I can’t wait to get home and see her. We tell him all the time that we love him so much.

Love at first sight

The Andersons welcomed Holli to their home in Olympia, Washington in March 2020.

The Andersons welcomed Holli into their Olympia, Wash., home in March 2020. She immediately melted the hearts of her new family, and her energy and playfulness added much-needed love and life.

The previous two years had been filled with grief, beginning with the death of Cami’s father in 2018. The following year, Cami’s brother passed away, and just a month prior, the mother of Cami’s husband, Kris, died. deceased. And while Rosko was happy and healthy, they knew he was a senior pet.

Cami’s daughter, Cali, began looking for another dog, hoping he would have time to learn from Rosko. She came across an online post for a puppy during a rescue in Texas. Her birthday was December 12 – a date shared with Cami’s mother-in-law.

“Cali felt it was a sign that Holli was right for us, and we finally agreed to adopt her after much discussion,” Cami said. “We now say it was the best decision of our lives.”

A rare condition

There was no sign that anything was wrong with Holli until Cami’s son Zach found her in the basement in May 2021. Holli, in obvious pain, struggled to get up.

“We first thought maybe she was eating something like a mushroom,” Zach said. “It was worse the next day, and that’s when we knew something was seriously wrong.”

Holli’s condition continued to deteriorate, but the cause remained elusive until two days later when an MRI revealed she had a brain cyst, a rare condition called arachnoid diverticula. The condition could be managed for a while with prednisone, but the steroid was not a long-term option as it would eventually weaken his immune system and cause liver damage.

“We didn’t know how long she would survive – the neurologist said it could be days, weeks, months or more – but it was such a joy to bring Holli home after the pain to think that we were going to lose her,” Cami mentioned.

Surgery was an option, albeit risky and expensive, but the family would need to contact a neurologist with expertise in the field. They were referred to WSU.

Hope at WSU

Holli recovers after the operation.

Holli started looking like herself after some time on prednisone, but the drugs were taking their toll by the end of August. At that time, WSU neurologist Dr. Chen-Allen had reviewed Holli’s case and felt that surgery could save her, however, she would have a long way to go to recover and there was 30% chance the disease will return.

“This surgery is an operation that few veterinary neurosurgeons will do, mainly because it can be intensive and the outcome can be very unpredictable,” Chen-Allen said. “Although we knew the surgery could be risky, it was Holli’s only chance to maintain a good quality of life without Prednisone.

In October, Holli arrived at WSU for surgery with Chen-Allen and resident Dr. Carlos Valerio-Lopez. The Andersons were constantly updated on Holli’s condition by her vets and fourth-year student Dane Collier, but it would be a 10-day roller coaster — and several nights in which there were doubts about her survival – before Holli finally returns home.

Initially she was unable to eat without a feeding tube and could not walk, but day by day Holli was improving. Now, several months into her recovery, she can eat on her own and even run. While the future is uncertain, the Andersons are grateful for each day spent with Holli.

Holli (right) and Rosko celebrate Holli’s second birthday.

“We feel truly blessed to have Dr. Chen-Allen, Dr. Valerio and Dane in our lives to help our sweet Holli – we just can’t thank them enough for the incredible care, compassion, warmth, understanding, positivity, support and encouragement,” Cami said.

University of Toronto researcher raises thorny question about COVID-19 death toll in British Columbia https://vetclinpathjournal.org/university-of-toronto-researcher-raises-thorny-question-about-covid-19-death-toll-in-british-columbia/ Sat, 29 Jan 2022 12:55:46 +0000 https://vetclinpathjournal.org/university-of-toronto-researcher-raises-thorny-question-about-covid-19-death-toll-in-british-columbia/

This weekend, British Columbia is certain to hit another grim milestone.

With 2,597 official deaths from COVID-19 so far, it is inevitable that the province will top 2,600 when the Department of Health releases the latest statistics on Monday (January 31).

On Friday January 28, British Columbia also reported that there were 990 “COVID positive people” in hospital.

During Friday’s briefing from Provincial Health Officer Dr. Bonnie Henry and Health Minister Adrian Dix, a chart was presented showing that British Columbia has far fewer deaths per capita than other large provinces.

“British Columbia has had some success compared to other jurisdictions, but there have been real losses,” Dix said.

The general tone was that COVID-19 has been a grueling battle over the past two years, but the province is doing its best to stem the worst effects of the disease.

This graph shows British Columbia’s death toll from COVID-19 compared to other major provinces.

Another graph shows that British Columbia’s hospitalization rate is lower than other major provinces.

This graph shows British Columbia’s record for hospitalizations due to COVID-19 compared to other major provinces.

This reassured British Columbians that the provincial government responded competently to the pandemic.

But an associate professor at the University of Toronto’s faculty of dentistry has publicly questioned whether British Columbia might be underreporting COVID-19 deaths to a much greater degree than other provinces.

Dr. Tara Moriarty directs the Moriarty Lab, which studies blood-borne bacterial pathogens. She has a cross-appointment in the Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto.

In one long twitter thread looking at provincial death rates, Moriarty suggested that there is a “possible 5-fold underdetection/underreporting” of COVID-19 deaths in British Columbia

It was based on “the daily new deaths predicted for Omicron, based on age-specific death rates, vaccination rates, boosters, vaccine protection against deaths from Omicron, the number of people in each group living in a region, minus the deaths reported so far in each region”.

Moriarty updates this information daily.

According to his analysis, Quebec is the only province in Canada with a total of COVID-19 deaths that matches his estimate of expected deaths.

It is an astonishing assertion.

Unsurprisingly, Moriarty’s analysis is generating quite a bit of discussion on social media, including among some doctors.

Steve Morgan, a professor in the UBC School of Population and Public Health, encouraged his Twitter followers to read Moriarty’s thread and then “ask questions accordingly.”

Here’s the problem with Morgan’s recommendation to ask questions accordingly: The vast majority of the population lacks the means to verify whether hospitals and health authorities are accurately reporting COVID-19 death statistics.

Still, this is an extremely serious problem, given the death toll. That aside from a growing controversy over whether the provincial government is responding appropriately to a airborne virus.

Sonia Furstenau, Green Leader from British Columbia, has already demanded an independent scientific table on COVID-19 and up-to-date data on people’s ages hospitalized with COVID-19.

In light of Moriarty’s finding that British Columbia has the fewest recorded deaths compared to expected COVID-19 deaths, don’t be surprised if Furstenau’s next request will be for an independent review of COVID-19 deaths. 19.

BC Green Leader Sonia Furstenau has called for an independent scientific panel to assess the BC government’s response to the COVID-19 pandemic.

A vascular disease

Part of the problem with assessing whether someone has died from COVID-19 is the widespread perception that it is a respiratory disease.

In fact, a growing number of scientific experts claim that it is actually a vascular disease with primary symptoms of a respiratory condition.

“Our public health officials insist on calling COVID a respiratory disease when it is clearly only the first phase of this complex syndrome,” said a group called Protect our province BC written on January 17 open letter to Minister of Health Adrian Dix.

“The concerning part of COVID-19 is the vascular injury which can manifest, often some time later, in damage to multiple organs, including the heart, lungs, liver and brain, causing long-term illness that is life-altering for some,” the letter continues. very little understood, Post covid syndrome or Long Covid suffer in silence and are classified in the statistics as ‘cured'”.

In his January 28 briefing – which came on the second anniversary of the first diagnosis of COVID-19, Henry did not mention that the disease is airborne or vascular.

In another briefing this month, Henry said COVID-19 will need to be managed like other respiratory illnesses, such as influenza, respiratory syncytial virus and enteroviruses that cause the common cold.

In one January 28 interview on CBC Radio One The stream along with Matt Galloway, Henry also argued that there is a high level of immunity due to the extent of vaccination against COVID-19.

“It’s like a really bad flu season,” Henry told Galloway.

She reiterated that the Omicron variant causes “predominantly mild disease”. And she predicted that British Columbia will have a “relatively mild spring”.

“We have the tools to deal with what comes next – and we’ve learned that,” Henry said.

She also claimed there was “intentional misinformation” being spread with the aim of “fomenting fear”.


Felix Cheung – who studies wellness – among 33 new or renewed Canada Research Chairs at the University of Toronto https://vetclinpathjournal.org/felix-cheung-who-studies-wellness-among-33-new-or-renewed-canada-research-chairs-at-the-university-of-toronto/ Wed, 12 Jan 2022 18:43:51 +0000 https://vetclinpathjournal.org/felix-cheung-who-studies-wellness-among-33-new-or-renewed-canada-research-chairs-at-the-university-of-toronto/

Does economic growth contribute to happiness? With its research project on the well-being of the population, the University of Toronto Felix Cheung hope to find out.

An assistant professor in the Department of Psychology at the Faculty of Arts and Sciences, Cheung calls the question of economic happiness one of the oldest debates in his field.

He cites, as an example, previous research he did on Hong Kong that found relatively low levels of life satisfaction despite high GDP per capita and long life expectancy – two common measures of well-being. be used by governments. And he notes that the same may be increasingly true in Canada after nearly two years of battling COVID-19.

“At a minimum, our well-being is not improving,” he says. “This is enough to consider: is our policy aligned with what Canadians want in life? “

Cheung also wishes to explore how governments can “can actually spend our economic growth to buy happiness,” noting that it is not so much economic prosperity as how it is distributed that may be most important.

“One of the agreements behind the rallying cry for police funding, I think, calls on us as a community to rethink how we spend government spending to promote the collective well-being of all.”

Cheung is one of 33 faculty members at the University of Toronto to receive a new or renewed Canada Research Chair in the last round of nominations announced on Wednesday (see full list below). The program supports exceptional work in a wide variety of fields. At the University of Toronto, that includes everything from marine epidemiology and precision medicine to research into sustainable bioproducts.

At the same time, the Canada Foundation for Innovation (CFI) – in collaboration with the CRC program – announced its support for Cheung and another researcher at the University of Toronto through his program. John R. Evans Leaders Fund (JELF), which helps universities pay for labs and equipment. The second researcher, Ji young Youn, is an Assistant Professor in the Department of Molecular Genetics at Temerty Medical School and a Scientist at the Hospital for Sick Children.

Professor Shaf Keshavjee from the University Health Network and the Faculty of Medicine of Temerty, also received $ 24 million in support through the New Frontiers in Research Fund for its project, The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Reconstruct organs.

“I would like to congratulate all the researchers at the University of Toronto who have been selected for a new chair or whose chair has been renewed, as well as those who have received funding from the John R. Evans Leaders Fund and the New Frontiers in Research Fund. said Lea Cowen, vice-president, research and innovation, and strategic initiatives.

“The federal government’s continued support for important work through Canada Research Chairs and other programs plays a key role in enabling our researchers to advance knowledge and foster innovation in a wide variety of ways. of domains.

The CRC program, established in 2000, invests up to $ 295 million per year to recruit and retain the best minds in Canada. It supports research in engineering, natural sciences, health sciences, humanities and social sciences.

In Cheung’s case, he plans to use level two funding from the Canada Research Chair to study the determinants, consequences and political relevance of population well-being using a multidisciplinary approach. He plans to explore three lines of research: What contributes to the well-being of the population and what can be done to create a more satisfying life for a given population? What are the desirable consequences of a happier society? And, finally, does the public support the idea of ​​using well-being as a major political indicator?

He says his work was inspired by observations he made while living in Hong Kong, where he noted that a high GDP per capita and a long life expectancy didn’t seem to make people happy.

“I could see that people were going through their lives without necessarily having a purpose,” he says. “This observation was later confirmed by my own data analysis.”

In fact, he discovered that the inhabitants of the region lived the least satisfying life in the developed world. “Hong Kong is a warning to the rest of the world,” he said. “A long and prosperous life is not necessarily a good life.”

Cheung joined the U of T in July 2020 and continued to research the topic. “There are so many world-class experts from different disciplines here,” he says. “I take advantage of it a lot because [the concept of] well-being is so multifaceted.

His proposal for the Canada Research Chairs Program extends not only to Ontario, but across the country. He adds that the program’s support will allow it to take the first step towards its long-term goal: to reinvent the way we measure societal progress.

“We need buy-in from different sectors – the public, government, business and non-governmental organizations,” he said. “This award is this initial membership that gives me hope that it is doable.”

He hopes his research can be used to measure well-being and its distribution across age groups, gender, sexual orientation, as well as racial and ethnic groups.

“Only if we measure it can we make other decisions about how we want to allocate resources,” says Cheung, adding that such research can help identify populations for which current policies do not. do not increase happiness.

“Nothing prevents the well-being of the population from becoming a major political indicator over the next century, as it reflects equality in our community which is currently not taken into account by existing political indicators. ”

Here are the new and renewed Canada Research Chairs at the University of Toronto:

New Canada Research Chairs

  • Benjamin blencowe from the Donnelly Center for Cellular and Biomedical Research at Temerty School of Medicine, level one in RNA Biology and Genomics
  • David Burnes of the Faculty of Social Work Factor-Inwentash, level two in prevention of elder abuse
  • Felix Cheung of the Department of Psychology of the Faculty of Arts and Sciences, level two in well-being of the population
  • Lihi Eder from the Department of Medicine at Temerty School of Medicine and Women’s College Hospital, level two in inflammatory rheumatic disease
  • Anna heath of the Dalla Lana School of Public Health and the Hospital for Sick Children, level two in the design of statistical trials
  • Omar F. Khan from the Institute of Biomedical Engineering of the Faculty of Applied Sciences and Engineering, level two in nucleic acid therapy
  • Thomas kislinger from the Department of Medical Biophysics of the Faculty of Medicine of Temerty and the University Health Network, level one in precision cancer medicine
  • Heather maclean of the Department of Civil and Mineral Engineering of the Faculty of Applied Sciences and Engineering, level one in evaluation of sustainable systems and technologies
  • Sonya macparland from the Department of Laboratory Medicine and Pathobiology of the Faculty of Medicine of Temerty and the University Health Network, level two in hepatic immunobiology
  • Kristin musselman from the physiotherapy department of the Faculty of Medicine of Temerty, level two in multi-morbidity and complex rehabilitation
  • Daniel I. Posen from the Department of Civil and Mineral Engineering of the Faculty of Applied Sciences and Engineering, level two in system-wide environmental impacts of energy and transportation technologies
  • Milica Radish from the Institute of Biomedical Engineering of the Faculty of Applied Sciences and Engineering, level one in organ-on-chip engineering
  • Chao wang from the Department of Immunology, Temerty School of Medicine and Sunnybrook Health Sciences Center, level two in Immunometabolism in Neuroinflammation
  • Tania Watts from the Department of Immunology of the Faculty of Medicine of Temerty, level 1 in anti-viral immunity
  • Ning yan of the Department of Chemical Engineering and Applied Chemistry of the Faculty of Applied Sciences and Engineering, level one in sustainable bioproducts
  • Ji-young youn from the Department of Molecular Genetics at Temerty School of Medicine and the Hospital for Sick Children, Level Two in Proteomics of Membrane-less Organelles

Renewed Canada Research Chairs

  • Ana Andreazza from the Department of Pharmacology and Toxicology of the Faculty of Medicine of Temerty, Level Two in Molecular Pharmacology and Mood Disorders
  • Daniel Bender from the Department of Historical and Cultural Studies, U of T Scarborough, Level One in Food and Culture
  • Robert bonin from the Leslie Dan Faculty of Pharmacy, level two in sensory plasticity
  • Brian connelly from the Department of Management at U of T Scarborough, Level Two in Integrative Personality Perspectives
  • Shelley craig of the Faculty of Social Work Factor-Inwentash, level two in sexual and minority youth
  • Daniel De Carvalho from the Department of Medical Biophysics of the Faculty of Medicine of Temerty and the University Health Network, level two in cancer epigenetics and epigenetic therapy
  • Elizabeth edwards of the Department of Chemical Engineering and Applied Chemistry of the Faculty of Applied Sciences and Engineering, level one in anaerobic biotechnology
  • Barbara Fall on of the Faculty of Social Work Factor-Inwentash, level two in child protection
  • Penny gilbert of the Institute of Biomedical Engineering of the Faculty of Applied Sciences and Engineering, level two in endogenous repair
  • Martin krkosek from the Department of Ecology and Evolutionary Biology of the Faculty of Arts and Sciences, level two in marine epidemiology
  • Warren lee from the Department of Medicine at the Temerty Faculty of Medicine and Unity Health Toronto, level two in endothelial permeability mechanisms
  • Jeffrey Meyer from the Department of Psychiatry of the Faculty of Medicine of Temerty and the Center for Addiction and Mental Health, level one in neurochemistry of major depressive disorder
  • Jean Rubinstein from the Department of Biochemistry of Temerty Faculty of Medicine and Hospital for Sick Children, Level One in Electron Cryomicroscopy
  • Mikko Taipale from the Donnelly Center for Cellular and Biomedical Research at Temerty School of Medicine, level two in Functional Proteomics and Proteostasis
  • Bebhinn treanor from the Department of Biological Sciences, U of T Scarborough, Level Two in Spatial Resolution Biochemistry
  • Andrea Tricco from the Dalla Lana School of Public Health and Unity Health Toronto, level two in knowledge synthesis
  • Amar Vutha from the physics department of the Faculty of Arts and Sciences, level two in precision atomic and molecular physics

Percheron Capital invests in Animal Dermatology Group, the largest group specializing in veterinary dermatology in the United States https://vetclinpathjournal.org/percheron-capital-invests-in-animal-dermatology-group-the-largest-group-specializing-in-veterinary-dermatology-in-the-united-states/ Thu, 06 Jan 2022 12:00:00 +0000 https://vetclinpathjournal.org/percheron-capital-invests-in-animal-dermatology-group-the-largest-group-specializing-in-veterinary-dermatology-in-the-united-states/

SAN FRANCISCO and IRVINE, Calif., January 6, 2022 / PRNewswire / – Percheron Capital (“Percheron”), a private equity firm focused on partnering with high quality essential service companies, today announced the acquisition of a controlling stake in Animal Dermatology Group , Inc. (“ADG”), the largest group of veterinary dermatologists in the United States As part of the transaction, ADG’s management team will continue to lead the company and the founders and veterinarians of ‘ADG will retain a significant stake in the business.

Along with this investment, ADG completed the acquisition of Animal Dermatology and Allergy Specialists (“ADAS”), a leading veterinary dermatology firm founded by Dr. Andrew Rosenberg, DACVD, at the service of New York Metropolitan area. With this addition, ADG’s specialist veterinary dermatology services now expand to 12 states across the country. Financial terms of the transactions were not disclosed.

ADG was founded in 1980 with a mission to provide the highest quality veterinary dermatological care to pet owners everywhere. The company has since grown into the largest U.S. group of veterinary dermatology specialists engaged in the diagnosis and treatment of acute and chronic skin conditions in companion animals, with more than 40 primary and satellite sites in the United States and the United States. foreigner. ADG also operates the largest American College of Veterinary Dermatology (ACVD) qualified dermatology residency training program in the United States, supporting the development of future dermatologists through comprehensive training and research. The company expects to build on its momentum and significant growth over the next several years, as the growing demand for high-quality veterinary dermatology services increases along with favorable industry winds, including increasing demand. number of pet owners.

Chris collins, co-founder and CEO of Percheron, commented: “We are delighted to partner with ADG to continue to develop the largest veterinary dermatology group in the country. There is a significant demand among pet owners for specialized skin care and ADG has built a network of the industry’s leading dermatologists to meet this need. We look forward to supporting ADG’s talented team as they continue to grow, innovate and provide the highest quality pet care across the country.

Dr. Craig griffin, ADG Co-Founder, said, “We founded ADG with a mission to make cutting-edge veterinary dermatology available to pet owners everywhere. We believe that we are at a natural inflection point in our history of growth, and this partnership with Percheron Capital allows us to take ADG to the next level and bring our innovative services to new and existing markets in order to support and caring for more pets and pet owners. ”

Dr. Wayne Rosenkrantz, co-founder of ADG, added, “We are incredibly proud of our team of physicians and ADG support staff for their commitment to medical excellence, innovation and expansion that make us a leader in veterinary dermatology. – markets in demand, such as the North East through our recent acquisition of ADAS, we are delighted to have a leading partner in Percheron Capital who shares our vision for growth and our commitment to excellent service.

Steven mrha, Chairman and CEO of ADG, said: “As we envision the next chapter in ADG’s evolution, we can’t think of a better partner than Percheron Capital. Their support and resources will allow us to continue to invest in our best physicians, support staff and cutting edge residency program, and accelerate our expansion organically and through acquisitions. “

About Percheron Capital
Percheron Capital is a private equity firm focused on partnering with exceptional teams to build market-leading service companies. The firm’s goal is to help high-quality companies accelerate their growth and increase their long-term value. Percheron manages more $ 850 million committed capital and focuses on investing in strong service companies in resilient end markets including animal health, automotive, education, food and beverage, health and wellness and the residential. For more information, please visit www.percheroncapital.com.

About the Animal Dermatology Group
Animal Dermatology Group (“ADG”) is the largest veterinary dermatology company in the United States, providing the highest quality care to pets with acute and chronic skin conditions. ADG has more than 40 primary and satellite sites where its veterinary dermatology specialists are actively involved in the provision of clinical care, research and academic training. For more information, please visit www.animaldermatology.com.

Media contacts
Percheron capital
Woomi yun / Erik Carlson
Joële frank, Wilkinson Brimmer Katcher
(212) 355-4449

SOURCE Percheron Capital

How Racism Early in Life Can Affect Long-Term Health https://vetclinpathjournal.org/how-racism-early-in-life-can-affect-long-term-health/ Mon, 03 Jan 2022 17:00:33 +0000 https://vetclinpathjournal.org/how-racism-early-in-life-can-affect-long-term-health/

The scientific evidence is crystal clear: Early experiences literally shape the architecture of the developing brain. This widespread understanding is leading to increased public support for universal kindergarten to improve school readiness for all children and level the playing field for children facing adversity. But here is something less known to the general public: With the brain connected to the rest of the body, the first experiences affect all of our biological systems, for better or for worse, starting in utero and all the crucial years that follow.

This larger message sends an important wake-up call: We all need to start paying more attention to the science that explains how excessive adversity can harm lifelong health as well as early learning. . This knowledge can help us better understand why people of color in the United States are at higher risk for developing chronic diseases and aging prematurely than white people.

With growing evidence for the early origins of disparities in physical and mental health, focusing solely on brain development and learning only confronts one dimension of the pervasive racism-related inequalities that plague American society. Case in point: Although the educational achievement gap between black and white children has narrowed from 30% to 40% since the 1970s, reducing racial disparities in health has been more difficult. For example, premature births and low birth weight, which are associated with an increased risk of cardiovascular disease and subsequent diabetes, occur at a rate about 1.5 to 1.6 times greater in non-Hispanic blacks than among non-Hispanic whites, and these gaps persisted for decades.

A growing body of scientific evidence tells us that the foundations for lifelong health are built during the prenatal period and early childhood. Factors that promote positive outcomes include supportive relationships, safe physical environments, and sufficient resources to meet basic needs such as food and shelter. Take any of these protective factors away or add the weight of undue hardship or threat outside the family, and you tip the scales toward a greater risk of future problems.

Despite the critical influence of these early years, long-term results are neither inevitable nor biologically predetermined. Of course, physical and mental health is influenced by our genetics, but the chances of problems actually developing are strongly influenced by the environments in which we live. Policies, conditions and resources that address inequalities and ensure conditions conducive to healthy young children, as early as possible, will help build a healthier society. In other words, it is racism, not race, that is at the root of the persistent disparities in physical and mental well-being.

Race is a social invention. All humans, regardless of their skin color, share 99.9% of the same genome. Residential segregation – one of the many converging consequences of systemic racism, personal discrimination and poverty – leads to significant inequalities in exposure to air pollution, other environmental toxins and violence neighborhood, as well as unequal access to nutritious food, stable housing, and education and health care. The differences between blacks and whites in preterm births have been well documented and linked to the stress associated with discrimination, regardless of socioeconomic status. Black children are three times more likely than white children to lose their mothers before the age of 10.

How can the impacts of adversity from racism in early childhood affect the health of a lifetime? One answer lies in the particular sensitivity of young and developing bodies to the physiological effects of a stressful environment. We all know what stress looks like physically, and science explains the source of these sensations.

When faced with an acute challenge or threat, the stress response systems inside our bodies activate. Blood pressure and heart rate increase. Stress hormones such as cortisol are elevated. The immune system triggers an inflammatory response to prepare for wound healing and fight infections. Metabolic systems mobilize blood sugar to fuel the “fight or flight” response. Once the threat is managed, the stress response (which can save lives) returns to baseline. But if the level of adversity remains high for long periods of time (from chronic discrimination or poverty, for example), the continued activation of the stress response can have a wear and tear effect on the inside of the body that leads to “toxic stress” and a host of health problems.

For example, excessive inflammation can affect multiple organ systems and increase the likelihood of developing heart disease and autoimmune disorders. Prolonged elevations in blood sugar can lead to insulin resistance, obesity, metabolic syndrome, and diabetes. Once we understand the biology of adversity and resilience, we can see how the excessive activation of stress early in life does not lead to inevitable illness but increases the risk of later problems, many of which include the pre-existing medical conditions associated with more serious illness from Covid19. The high prevalence of these conditions among people of color may thus explain part of the marked racial / ethnic differences in hospitalization and death rates from the pandemic.

Much of the public debate on disparities in health outcomes focuses on unequal access to medical care, unequal treatment in the health system, and the impacts of lifestyles and individual responsibility on health. adulthood. But science tells us that preventing or lessening the effects of adverse experiences and exposures in infancy could be as important to long-term health as the conditions we live in as adults and the medical care we receive. .

A better understanding of how the synergistic tensions of systemic racism, interpersonal discrimination and intergenerational poverty can be integrated into the body can be a powerful tool on the road to a healthier and more just world. Science tells us that the road must begin in the first years of life.

10.1146 / knowable-121121-1

This article originally appeared in Known magazine, an independent journalistic company of Annual Reviews. Register to receive the newsletter.

The art of being a happy pessimist https://vetclinpathjournal.org/the-art-of-being-a-happy-pessimist/ Sat, 01 Jan 2022 19:30:11 +0000 https://vetclinpathjournal.org/the-art-of-being-a-happy-pessimist/

There is a cult of “positivity” that rules the world. Through countless self-help books, banal social media slogans, and WhatsApp hello messages, this cult will have you believing “Think Positive” is the magic pill for mental health. Pop one to instantly make that glass half empty half full and all around you bright and sunny.

But isn’t it painful to seem continually optimistic even when you’re anxious and bogged down? And what about those of us who naturally take a more cautious view of the world? When things are very clearly not going well, can we really activate that “be optimistic” button and feel good?

Turns out, practically, physiologically, and psychologically, pessimism isn’t always the bad guy popular culture claims to be. And, in more than one way, certain forms of pessimism can also work to our advantage.

The case of constructive pessimism

First of all, a positive attitude is great. We all love the happy people around us. The melancholics are short. And our lived experience tells us that life is easier when you are hopeful and jovial. Additionally, there is a lot of research suggesting that optimism has many health benefits. Studies have shown that optimistic people are less prone to heart disease, strokes and cancer. So it’s no wonder that there is relentless social pressure on us to be eternal optimists. This is where the problem lies.

Experts believe our moods and views are part of an optimism-pessimism spectrum. On opposite ends of this spectrum are the pure optimists, who can be detached from reality, and the pure pessimists, who can be unhappy, according to Dr. Elizabeth Scott, award-winning author and blogger on stress management and wellness. emotional.

While purists are a small minority, the majority of us fall somewhere in the middle of the spectrum. And while, generally, most of us are optimistic about some areas of our lives and not others, our natural state of being leans towards one of the two ends of the spectrum, writes Dr Scott in a medically revised article.

So, in the words of Dr Alok V Kulkarni, a senior consultant psychiatrist at a Hubli-based mental health institute, “optimism, while desirable, is not the default state of mind for everyone.” . It depends on various factors – birth traits, stable upbringing, positive life events, sense of security, and positive feelings about self-esteem, self-image, self-esteem and self-identity – says Dr Kulkarni. So, it follows that the majority of people are either generally optimistic or generally pessimistic due to their birth traits and the type of life they have had from infancy through adolescence and youth.

Most importantly, “it is not possible to fundamentally change a person,” says Dr Raghu K, chief psychiatrist at a multi-specialty hospital based in Bengaluru. According to him, there is a socio-cultural dimension in the way we think about optimism and pessimism. “Nothing is waste in nature,” he says. If a particular trait exists, then it has its uses in our life and survival. But how we view or rank the trait – positive or negative, good or bad – is only a social construct. Simply put, the company has its own way of creating a narrative. If he views a particular trait favorably, then anyone who exhibits that trait is referred to as a positive personality, and vice versa.

Against the backdrop of pessimism, we know this has been a useful trait throughout our evolution, because being nervous, anxious, and worried about things that might go wrong has kept us alive. But most modern societies, including our own, view pessimism as a negative emotion. And so those of us who are not naturally optimists are desperate to deny and stifle our pessimistic instincts, even though the struggle to become optimistic is sometimes more painful than being a pessimist.

The irony here is that the tendency to force positivity and resist negativity can actually hurt the truly anxious. Psychologist and writer Dr. Douglas LaBier says mental health and well-being comes from embracing “bad feelings” and not pushing them away. He says that while meditation, yoga, and other mind-body practices can help us deal with negativity, the process must begin with accepting our so-called negative emotions.
So, to sum it up in Dr. Raghu’s words, “if you are born with a particular trait, you must embrace it and regard it as your strength”. And this also applies to pessimism.

How to accept pessimism

That’s not to say that we should all proactively develop a more pessimistic outlook on life. But if we are naturally inclined to have a pessimistic view, how can we use this trait as a strength?

Some of the benefits of having a pessimistic outlook are intrinsic to the way these personalities think and behave. More often than not, they expect negative results and are pleasantly surprised when things go well. So it’s no surprise that a 2013 study published in the Journal of Research in Personality shows that people with negative outlooks are better than their more optimistic peers when it comes to building safety nets, to prepare (practically and emotionally) for bad situations, and hold on to their worldview in crises. We can also assume that since pessimists focus on detecting obstacles in their path, they are better able to assess risks and avoid them.

Research indicates that a pessimist’s chronic tendency to have negative expectations (dispositional pessimism in psychologist parlance) can also be a big advantage, especially in the relationship arena.

A study published in the Journal of Personality and Social Psychology concludes that sometimes too much optimism can be a handicap in a marriage or relationship because it prevents couples from proactively engaging in problem solving. Conversely, couples who take a more cautious approach to their relationship tend to experience more long-term success and satisfaction, as they start out with lower expectations about each other’s ability to cope and, therefore, to make more efforts.

There is also a way to use pessimism as a strategy for dealing with anxiety and dealing with difficult real life situations. Psychologists call this “defensive pessimism,” and it is based on the fact that people with negative outlooks tend to imagine worst-case scenarios over and over and become anxious. However, practitioners of defensive pessimism exploit this trait to perform better than they would by thinking positively.

When a defensive pessimist begins to feel anxious about an event or situation, they first drastically lower their expectations, and then think vividly and specifically about all the things that could go wrong. In the process, she is able to create a plan of action to deal with any potential setbacks. To better understand, think about an upcoming public speaking event that is making you nervous. Using the principles of defensive pessimism, start by telling yourself it’s going to be a disaster. Then imagine in detail all the worst-case scenarios: you forget a key data point, you stumble on the microphone wire, etc.

Seeing this disaster unfold in your mind, you prepare to take concrete mitigating action – carry a landmark card with the data point, ask the organizers for a wireless microphone, and more. Thus, you feel more in control and therefore less anxious.

Best of all, of course, you are now very well prepared, better prepared than you would be if you thought the event would go well.

Does Pessimism Really Affect Your Health? Ask the Japanese

Everyone and their aunt believe that optimists are healthier than pessimists. The reality is, for every study that claims the health benefits of optimism, there is one that shows the longer life expectancies of pessimists. Finnish study links pessimism to heart disease, but UK study finds no link between positivity and longevity. Thus, contrary to popular perception, the scientific evidence to support the health benefits of optimism or the detrimental effects of pessimism is inconclusive, contradictory and controversial.

A 2017 study comparing the adult populations of America and Japan is a good reference in this context. Entitled “Linking Positive Affect to Blood Lipids: A Cultural Perspective,” the study found that Americans were more likely to have healthier cholesterol levels and less likely to be overweight if they were optimistic. But no such connection could be found for the Japanese. In East Asian cultures, such as Japan, positive emotions are not viewed favorably and are seen as a distraction. But paradoxically, the Japanese are known to lead long and healthy lives. So, if pessimism is unhealthy, what explains the Japanese paradox?

It is impossible to find the exact cause and effect in studies like this. But look at it with a socio-cultural lens and the answer seems clear. In American society optimism is a strongly reinforced value while in Japan the cultural emphasis is on living with a cautious attitude. So, it may not be optimism or pessimism, but our ability to live in tune with the dominant culture that makes us healthy or unhealthy.

The worst is yet to come?

You can trust the Swedes to be the first to greet anything to the contrary. This is also true for the happy pessimism which is gaining a lot of space in Sweden. Battling the pressure to relentlessly be seen as positive, many Swedes encourage a growing cult that promotes healthy negative thinking. In fact, a course titled “Negative Thinking: It Won’t Get Any Better Than This” by practical philosopher and psychologist Ida Hallgren ran out of applications in a day.

Psychologist and comedian Mattias Lundberg, who has co-authored a book on happy pessimism, writes that there’s no denying the power of optimism, but the self-help industry has “twisted the term.”

“Unlimited positivity has in a way become a necessary condition for happiness. And in this hypothesis could lie a great danger”, he would have declared in an article published in a large Swedish newspaper.

Hallgren’s course, by the way, is built around three phases of pessimism. It begins with the Greek Stoics, continues through to 19th century pessimism “guru” Arthur Schopenhauer and ends with Buddhism. Hallgren explains that the negative thinking movement is about recognizing reality, “even the ugliest of things,” not expecting the worst in life.

Eastern Health announces temporary changes to services https://vetclinpathjournal.org/eastern-health-announces-temporary-changes-to-services/ Sat, 01 Jan 2022 12:44:00 +0000 https://vetclinpathjournal.org/eastern-health-announces-temporary-changes-to-services/

Eastern Health has announced temporary changes to services, effective January 4, 2022.

Eastern Health says it will focus on urgent and emerging acute services at health care sites across the city, including the Health Sciences Center, St. Clare’s Mercy Hospital and Dr LA Miller Center.

These changes will reallocate resources to help the COVID-19 public health response, such as the administration of COVID-19 booster vaccines and COVID-19 swab clinics.

Urgent and urgent appointments are underway in the following areas: adult outpatient clinics, regional medicine program, child and women’s health, and rehabilitation, palliative care and geriatric medicine services.

The regional surgical services will perform urgent and emerging cardiac and cancer surgeries. A full list of impacts on specific services is available below.

Medical imaging

  • The medical imaging program will perform examinations as a priority. Patients will only be contacted if their appointment has been canceled for MRI (Magnetic Resonance Imaging), CT (Computer Tomography), Ultrasound, Mammography, X-ray, Nuclear Medicine, PET ( Positron Emission Tomography) and BMD (bone densitometry)

Children’s and women’s health

  • All Maternal-Fetal Assessment Unit (MFAU) and prenatal appointments will continue.
    For all other appointments, only patients whose appointment is in progress will be contacted for confirmation. If you have not been contacted, your appointment is canceled.

Provincial Cancer Care Program

  • All radiotherapy and chemotherapy appointments will take place. Patients will be contacted directly if there is a change in their clinic appointments.

Ambulatory laboratory services (January 4-7, 2022): All sites in the Eastern health region

  • All non-urgent appointments have been canceled.
  • Urgent / emerging laboratory testing and services will continue.
  • Eastern Health ambulatory blood collection sites are limited to urgent blood collection only. This includes blood tests for patients requiring: INRs (International Standardized Ratios), therapeutic drug level monitoring testing and, for cancer patients, monitoring cancer clinic profiles and other related required tests. to cancer.

Eastern Health says only patients with ongoing appointments and procedures will be contacted at this time.

In addition, the health authority has extended restrictions on visitors following the upsurge in COVID cases.

All in-person visits to inpatients in hospitals and residents of long-term care homes, personal care homes, community care homes and assisted living facilities are suspended until further notice and the general public is advised. requested not to visit any patient or resident during this time.