Real data links rosuvastatin to adverse kidney effects

According to a study published online July 19 in the Journal of the American Society of Nephrology.

Jung-Im Shin, MD, of the Johns Hopkins Bloomberg School of Public Health in Baltimore, and colleagues used anonymized electronic health record data and analyzed 152,101 new rosuvastatin users and 795,799 new atorvastatin users from 2011 to 2019. The inverse probability of treatment-weighted hazard ratios of hematuria, proteinuria, and KFRT associated with rosuvastatin were estimated. The dose effect of rosuvastatin was examined on haematuria and proteinuria.

During a median follow-up of 3.1 years, researchers identified hematuria in 2.9% and proteinuria in 1.0% of patients. Rosuvastatin use was associated with increased risks of hematuria, proteinuria, and KFRT compared to atorvastatin (relative risks, 1.08, 1.17, and 1.15, respectively). Forty-four percent of patients with an estimated glomerular filtration rate of 2 were prescribed high-dose rosuvastatin (20 or 40 mg daily) even though current labeling suggests a reduction in dosage (maximum daily dose, 10 mg) for patients with severe chronic renal failure. With a higher dose of rosuvastatin, the risks of hematuria and proteinuria were higher.

“Because rosuvastatin may cause proteinuria and hematuria, especially with high dose, high dose rosuvastatin may not deserve the risk, even if small, especially for patients with advanced renal failure “Shin said in a statement.

Several authors disclosed financial ties to the pharmaceutical industry.

Real data links rosuvastatin to signs of kidney damage

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