Vet Clin Path Journal http://vetclinpathjournal.org/ Wed, 21 Jul 2021 23:31:18 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://vetclinpathjournal.org/wp-content/uploads/2021/05/cropped-icon-32x32.png Vet Clin Path Journal http://vetclinpathjournal.org/ 32 32 Colorado vet brings 12,000 rabies vaccines to Kenya to fight protracted outbreak https://vetclinpathjournal.org/colorado-vet-brings-12000-rabies-vaccines-to-kenya-to-fight-protracted-outbreak/ https://vetclinpathjournal.org/colorado-vet-brings-12000-rabies-vaccines-to-kenya-to-fight-protracted-outbreak/#respond Wed, 21 Jul 2021 23:07:00 +0000 https://vetclinpathjournal.org/colorado-vet-brings-12000-rabies-vaccines-to-kenya-to-fight-protracted-outbreak/

DENVER – At Dr. Julie Kelly’s Denver Veterinary Clinic, they work hard to keep dogs, cats and other small animals healthy.

“I just had a tooth extraction on a cat this morning,” Kelly said.

But Kelly’s work next month will extend far beyond this clinic.

“Everyone knows rabies in Kenya,” Kelly said. “They know someone who has been infected.”

As the rest of the world continues to grapple with the global pandemic and COVID-19 variants, Kelly and her team attempt to deal with an old but pesky disease.

For the eighth time in ten years, Kelly is preparing rabies vaccines and is traveling with a team to Kenya next week.

“What we are working on is the rabies epidemic that they are fighting,” Kelly said.

Dogs and cats often contract rabies from wild animals in nearby Tsavo National Park.

“Dogs with rabies, they get vicious and they can attack humans,” Kelly said. “And most cases of rabies are in young children going to and from school.”

“There are reasons to be afraid,” said Katherine Baxter, COO of ANAW-USA, also known as the African Animal Welfare Network. “These communities live on the border of Tsavo National Park, which is home to a very wide range of wildlife dangerous to humans.”

Hundreds of Kenyans line up with their dogs and cats when Dr Kelly’s mobile clinic arrives.

“And generally we try to steer clinics around times when school is not in session,” Kelly said. “Because it’s usually the children who bring the animals to the clinics. “

Kenyans love their pets as much as we do. Now they know and trust Kelly and her team, who also put necklaces on any animals that get vaccinated, so locals know they’ve been vaccinated.

“It’s a source of pride for many homes,” Kelly said. “They ask, ‘Can I have a collar to show that my pet has been vaccinated? “”

“Obviously, we can’t eliminate the rabies that occurs in wild animals all together,” Baxter said. “But just trying to make sure that the vectors that transmit rabies to humans are managed.”

The mission is a labor of love for a team planning their biggest effort ever – with a goal of vaccinating 12,000 dogs and cats in three weeks.

“It’s a very serious disease and I think we take for granted all the preventative work that has been done in the United States,” Baxter said.

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Relay For Life event has raised $ 54,000 so far for the American Cancer Society – ClarkCountyToday.com https://vetclinpathjournal.org/relay-for-life-event-has-raised-54000-so-far-for-the-american-cancer-society-clarkcountytoday-com/ https://vetclinpathjournal.org/relay-for-life-event-has-raised-54000-so-far-for-the-american-cancer-society-clarkcountytoday-com/#respond Wed, 21 Jul 2021 23:05:03 +0000 https://vetclinpathjournal.org/relay-for-life-event-has-raised-54000-so-far-for-the-american-cancer-society-clarkcountytoday-com/

The event is over; an online auction will take place from August 19 to 22

VANCOUVER – Volunteers for the American Cancer Society’s annual Relay for Life in Clark County have gathered for a “Parking Lot – Tailgate Event” at the Vancouver Mall on July 17th. The event has raised funds for cancer research and patient services for the American Cancer Society for 35 years in Clark County.

Volunteers for the American Cancer Society’s Annual Relay for Life in Clark County gathered for a “Parking Lot – Tailgate Event” at the Vancouver Mall on July 17th. The event raised funds for cancer research and patient services for the American Cancer Society for 35 years in Clark County. Photo courtesy of Ken Waz

“The onset of the pandemic in 2020 threw us, and really all nonprofit events, for a big loop,” said event co-lead Libby Mongue-Wymore. “Everything has been put on hold and in a phase of limbo. We got together last year and have done our best with online and social distancing events, but the chance to be able to connect in person has been a great loss to our community of volunteers, caregivers and survivors.

A year later and some tweaking with state COVID guidelines allowed the event to come together with a new version of the “Tailgate party” of the community event held in the upper parking lot of the Vancouver Mall.

“We were delighted to partner with the Vancouver Mall,” said Lisa Houser, co-manager of the event. “The space was perfect for our party in the parking lot and the opportunity to get together and be able to see each other face to face for the first time in almost two years!”

The event kicked off by celebrating cancer survivors in the community with a Hope Car Parade. Survivors were greeted with cheers, cowbells and excitement as they paraded through the mall and back to the tailgate parking lot. Community businesses donated items to help assemble gift bags for cancer survivors, and the committee served a light lunch to more than 50 survivors after the parade.

Thanks to everyone's hard work, the event has currently raised over $ 54,000 for the American Cancer Society.  Photo courtesy of Ken Waz
Thanks to everyone’s hard work, the event has currently raised over $ 54,000 for the American Cancer Society. Photo courtesy of Ken Waz

The party continued after, with fundraising teams setting up spaces in the parking lot for fundraising, games and music streaming with help from KXRW. The Vancouver Mall hosted a photo scavenger hunt, Los Pepe’s hosted a cash back dinner, Utopia Salon donated haircuts for donation to wig programs, and Able Bodied Center of Therapeutics Massage released its trailer. massage, in addition to the activities organized by the fundraising teams.

Later in the evening, “Luminarias on the Lawn” took place. The white luminaria bags, each representing someone’s cancer story, were set up and displayed for people to walk through. “This was our first time trying a hatchback version of our event, we had no idea how it would go,” said Mandy Dunn, co-manager of the event. “We were overwhelmed with the number of luminaria bags, so much so that we had the volunteers go out and buy more tea lights, even eliminating the supply from the nearest store!”

The Clark County Relay For Life is not yet complete, an online auction will be held August 19-22 with an additional opportunity to raise funds for the American Cancer Society. Items sold at auction can be viewed and bid during this period at https://www.32auctions.com/2021HopefromHome

Thanks to everyone’s hard work, the event has currently raised over $ 54,000 for the American Cancer Society.

To support the Clark County American Cancer Society Relay For Life, donate at www.clarkcountyrelay.org and follow it on Facebook at www.facebook.com/clarkcowarelay.

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Efficacy of Covid-19 vaccines against variant B.1.617.2 (Delta) https://vetclinpathjournal.org/efficacy-of-covid-19-vaccines-against-variant-b-1-617-2-delta/ https://vetclinpathjournal.org/efficacy-of-covid-19-vaccines-against-variant-b-1-617-2-delta/#respond Wed, 21 Jul 2021 21:00:45 +0000 https://vetclinpathjournal.org/efficacy-of-covid-19-vaccines-against-variant-b-1-617-2-delta/

Study design

We used two approaches to estimate the effect of vaccination on the delta variant. First, we used a negative test case-control model to estimate vaccine efficacy against symptomatic disease caused by the delta variant, compared to the alpha variant, over the period of circulation of the delta variant. This approach has been described in detail elsewhere.ten In short, we compared the vaccination status of people with symptomatic Covid-19 with the vaccination status of people who reported symptoms but tested negative. This approach makes it possible to control biases related to health-seeking behavior, access to tests and identification of cases.

For the secondary analysis, the proportion of people with cases caused by the delta variant compared to the main circulating virus (the alpha variant) was estimated according to vaccination status. The underlying assumption was that if the vaccine had some efficacy and was equally effective against each variant, a similar proportion of cases with either variant would be expected in unvaccinated and vaccinated people. Conversely, if the vaccine was less effective against the delta variant than against the alpha variant, the delta variant should represent a higher proportion of cases occurring more than 3 weeks after vaccination than in unvaccinated persons. Details of this analysis are described in Section S1 of the Supplementary Annex, available with the full text of this article on NEJM.org. The authors guarantee the accuracy and completeness of the data and the reliability of the trial to the protocol.

Information source

Vaccination status

Data on all people in England who have been vaccinated with Covid-19 vaccines are available in a National Immunization Management System. Data for vaccinations that had taken place up to May 16, 2021, including the date of receipt of each vaccine dose and the type of vaccine, were retrieved on May 17, 2021. Vaccination status was categorized as receipt one dose of vaccine among people who onset of symptoms occurred 21 days or more after receiving the first dose until the day before receiving the second dose, such as receiving the second dose in people whose onset of symptoms occurred 14 days or more after receiving the second dose, and as receiving the first or second dose in people whose symptoms began 21 days or more after receiving the first dose ( including any period after receiving the second dose).

SARS-CoV-2 test

Polymerase chain reaction (PCR) testing for SARS-CoV-2 in the UK is performed by hospital and public health laboratories, as well as community testing using drive-thru or at-home testing , which are available to anyone with symptoms compatible with Covid-19 (high temperature, continued new cough, or loss or change in smell or taste). Data from all positive PCR tests between October 26, 2020 and May 16, 2021 have been extracted. Data on all negative community tests recorded among those reporting symptoms were also extracted for negative test case-control analysis. Children under the age of 16 on March 21, 2021 have been excluded. Data were limited to those who reported symptoms, and only those who had tests within 10 days of symptom onset were included, to account for the reduced sensitivity of PCR tests beyond this. period.25

Variant identification

Whole genome sequencing was used to identify the delta and alpha variants. The proportion of all positive samples that were sequenced increased from around 10% in February 2021 to around 60% in May 2021.4 Sequencing is performed in a network of laboratories, including the Wellcome Sanger Institute, where a high proportion of samples have been tested, and whole genome sequences are assigned to Public Health England variant definitions on the basis of mutations.26

The target status of the Spike gene on PCR was used as a second approach to identify each variant. The laboratories used the TaqPath test (Thermo Fisher Scientific) to test three target genes: spike (S), nucleocapsid (NOT), and the open reading frame 1ab (ORF1ab). In December 2020, it was noted that the alpha variant was associated with negative tests on the S target, therefore S the target-negative status was then used as a proxy for the identification of the variant. The alpha variant represents between 98% and 100% of S negative target results in England. Among the sequenced samples that tested positive for S Target, the delta variant was present in 72.2% of samples in April 2021 and in 93.0% in May (as of May 12, 2021).4 For the negative test case-control analysis, only samples that had been tested in laboratories with the use of the TaqPath assay were included.

Data binding

The three data sources described above were related to the use of the National Health Service number (a unique identifier for each person receiving medical care in the UK). These data sources were also linked with data on date of birth, last name, first name, postal code, and patient sample identifiers and dates.

Covariates

Multiple covariates that may be associated with the likelihood of being offered or accepted a vaccine and the risk of exposure to Covid-19 or specifically to one of the variants analyzed were also extracted from the National Immunization Management System and test data. These data included age (in 10-year age groups), sex, multiple deprivation index (a national indication of the level of deprivation based on small geographic areas of residence,27 assessed in quintiles), race or ethnicity, nursing home status, overseas travel history (i.e. outside the UK or Ireland) , geographic region, time period (calendar week), social and health worker status, and status of being in a clinically extremely vulnerable group.28 In addition, for the negative test case-control analysis, a history of SARS-CoV-2 infection before the start of the vaccination program was included. People were considered to have traveled if, when requesting a test, they claimed to have traveled outside the UK and Ireland within the previous 14 days or if they had been tested in a quarantine hotel or so ‘they were in home quarantine. Postal codes were used to determine the multiple deprivation index, and unique property reference numbers were used to identify nursing homes.29

Statistical analyzes

For the negative test case-control analysis, a logistic regression was used to estimate the odds of having a symptomatic case of Covid-19 confirmed by PCR among vaccinated people compared to unvaccinated people (control). The cases were identified as having the delta variant by sequencing or if they were S positive target on the TaqPath PCR assay. The cases were identified as having the alpha variant by sequencing or if they were S negative target on the TaqPath PCR test.

If a person had tested positive multiple times during a 90-day period (which may represent a single episode of illness), only the first positive test was included. A maximum of three randomly selected negative test results were included for each person. Negative tests in which the sample was taken within 3 weeks before a positive result or after a positive result could have been false negatives; therefore, these were excluded. Tests that had been administered within 7 days of a previous negative result were also excluded. People who had already tested positive before the analysis period were also excluded in order to estimate the effectiveness of the vaccine in fully susceptible people. All covariates were included in the model as done with previous test negative case-control analyzes, with calendar week included as a factor and no interaction with region.

In regards to S target status positive or negative, only people who had tested positive on the other two PCR genetic targets were included. Assignment to the delta variant based on S the target status has been limited to the week starting April 12, 2021 and beyond in order to aim for a high specificity of S positive target test for the delta variant.4

The vaccine’s effectiveness for the first dose was estimated in people whose symptom onset date was 21 days or more after receiving the first dose of vaccine, and the effects of the vaccine for the second dose were estimated in people whose symptom onset date was 14 days or more after receiving the second dose. A comparison was made with unvaccinated people and with people who experienced symptoms within 4 to 13 days after vaccination to help explain the differences in underlying risk of infection. The period from the day of vaccine administration (day 0) to day 3 has been excluded because reactogenicity of the vaccine may lead to an increase in testing which skews the results, as previously described.ten

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Unilabs to Deploy Ibex AI-Assisted Cancer Diagnostics Platform Across Europe https://vetclinpathjournal.org/unilabs-to-deploy-ibex-ai-assisted-cancer-diagnostics-platform-across-europe/ https://vetclinpathjournal.org/unilabs-to-deploy-ibex-ai-assisted-cancer-diagnostics-platform-across-europe/#respond Wed, 21 Jul 2021 19:00:10 +0000 https://vetclinpathjournal.org/unilabs-to-deploy-ibex-ai-assisted-cancer-diagnostics-platform-across-europe/

Unilabs and Ibex are teaming up to make cancer diagnosis more precise, faster and more targeted.

Under the new agreement, Unilabs will deploy Ibex’s AI-powered multi-tissue Galen platform in pathology labs across Europe. Supported by advanced machine learning algorithms, the platform evaluates tissue biopsies in real time to provide valuable information on tumor grade and size.

Other notable features of the Galen include worklists for case prioritization and cancer heatmaps for increased diagnostic accuracy.

“This cutting-edge AI technology will help our teams quickly prioritize urgent cases, speed up diagnosis and improve quality by adding an additional set of digital eyes,” said Dr. Christian Rebhan, Medical and Operations Director at Unilabs.

Rebhan continued, “When it comes to cancer, the earlier you catch it, the better the prognosis. Therefore, getting critical results faster will help save lives. The partnership with Ibex underlines Unilabs’ pioneering role in digital pathology and represents a further step in our ambition to become the most digital diagnostic service provider in Europe. “

Galen by Ibex is CE marked for detection of breast and prostate cancer. Unilabs will deploy the Ibex platform in 16 countries, starting with Sweden.

“Ibex is transforming cancer diagnostics with innovative AI solutions along the diagnostic pathway,” said Joseph Mossel, CEO and co-founder of Ibex Medical Analytics.

“We are excited to partner with Unilabs to deploy our AI solutions and give their pathologists faster turnaround times and quality diagnostics. This cooperation follows an in-depth evaluation of our technology at Unilabs and demonstrates the robustness and utility of our platform for daily clinical practice. . “

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Afghanistan pullout indicates American faith is losing ground https://vetclinpathjournal.org/afghanistan-pullout-indicates-american-faith-is-losing-ground/ https://vetclinpathjournal.org/afghanistan-pullout-indicates-american-faith-is-losing-ground/#respond Wed, 21 Jul 2021 13:10:47 +0000 https://vetclinpathjournal.org/afghanistan-pullout-indicates-american-faith-is-losing-ground/

Illustration: Liu Rui / GT

Twenty years ago, at the start of the war in Afghanistan, I was a reporter in New York.

One Sunday in late fall, I was driving with a friend in Newtown, a small town in Connecticut. The editorial called me and told me that American troops were already on the ground in Afghanistan. They asked me how the locals reacted. The quiet life in this small town stands in stark contrast to the war thousands of miles away in Afghanistan. I even remember when I interviewed two high school kids in New York, they couldn’t even find Afghanistan on a map.

But in keeping with President Bush’s strategic vision, the fight against Al Qaeda terrorists was designed to ensure that Americans can have the calm and peaceful lives that I have seen. The American elites have not even hesitated to call it a “war of faith”. Why? Because they believe that only a radical change in the beliefs of what is considered a low level civilization can eradicate the soil of terrorism. The small town quickly faded from my memory. That was until one day in 2012 when I suddenly heard the news that there had been a shootout at the town’s middle school. A 20-year-old named Adam Lanza shot dead 26 people, including 20 children between the ages of six and seven, as well as six adult staff members. Reports at the time described the incident as “a dark cloud over this area forever.”

In Afghanistan, the death toll of US troops has exceeded 2,000. In addition, tens of thousands of Afghans are dying or being displaced, struggling between life and death.

From the perspective of the United States, the war may not have been a complete failure. At the very least, the war that lasted two decades crushed Al-Qaeda and ensured that there were no more attacks here by outside terrorists like the attacks of September 11, 2001.

But the gunfire in Newtown is a good illustration of the abandonment of Afghanistan by the United States. Quiet life in the United States has been disrupted by threats from outside, as well as dangers from within. Such shootings are a microcosm of the growing problems in American society.

A country powerful enough to send troops to fight two world wars at the same time is incapable of dealing with its own social problems. An empire that was desperately trying to spread its faith to the world through wars, looked back and found it could no longer hold its own.

Afghan politics have been in disarray for a long time since 1978. This is mainly due to the state’s inability to reach consensus among different ethnic groups and tribes on the basis of political dialogue. This is of course linked to the religious beliefs of the local ethnic groups.

It will be a slow process to change the political ecology of Afghanistan. The intervention of outside forces by military means will only make the process more complicated and difficult. Empires in geopolitical competition always focus only on their own interests and security – this is one of the reasons they are so deeply trapped in this “graveyard of empires”.

As US troops retreat from Afghanistan, opinion columnist David Brooks published an article titled “The Crisis of American Identity” in the New York Times, in which he said: “We probably won’t. not fighting well for hearts and minds if we see ourselves abandoning our allies in places like Afghanistan. ”

The sentiment expressed by the author vis-à-vis the American withdrawal once again proves three facts. First, the propagation and expansion of Western civilization over the past 500 years relies on the support of the power of capital. The decision to withdraw from the Biden administration is made based on the ability of the United States to know how much it can financially afford to be involved in Afghanistan. Two decades of war in Afghanistan cost the United States more than $ 2 trillion. Over 2,400 American soldiers have been killed and over 20,000 injured.

Second, Brooks regretted that the United States could no longer continue to spread its ideals in Afghanistan. He seems to have deliberately forgotten that the US military diffuses values ​​through wars. During this 20-year war, more than 47,000 Afghans were killed or maimed, according to incomplete statistics. It is even more difficult to count the number of displaced refugees.

Third, to spread faith and beliefs abroad, the United States must strengthen the cohesion of its own beliefs. People will not believe that a United States that is full of sweeping conflict, heavy gunfire, and seeing a growing gap between rich and poor could become a “beacon of faith.” So-called claims that the United States wants to spread faith or universal values ​​are just excuses to cover up the war.

The author is editor-in-chief at People’s Daily and currently a senior researcher at the Chongyang Institute for Financial Studies at Renmin University of China. dinggang@globaltimes.com.cn. Follow him on Twitter @dinggangchina

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Child with rare genetic syndrome treated within 2 years https://vetclinpathjournal.org/child-with-rare-genetic-syndrome-treated-within-2-years/ https://vetclinpathjournal.org/child-with-rare-genetic-syndrome-treated-within-2-years/#respond Wed, 21 Jul 2021 09:46:15 +0000 https://vetclinpathjournal.org/child-with-rare-genetic-syndrome-treated-within-2-years/

It is difficult to diagnose a rare disease. Identifying a treatment can take years of trial and error. At the fortuitous intersection of research expertise, a sick patient in this case a child, and innovative technology, Bachmann-Bupp syndrome has gone from a list of symptoms to a treatment. succeeded in just 16 months.

The article chronicling this ultra-rapid scientific response to Bachmann-Bupp syndrome was published in the open access journal eLife.

For more than 25 years, André Bachmann, professor of pediatrics at Michigan State University, has studied the ODC1 gene. This gene and its protein product ODC, which produces polyamines, are crucial for cell survival and contribute to many developmental processes, including muscle tone and motor skills in children.

From Bachmann’s research, he also knew that the drug difluoromethylornithine, or DFMO, (sometimes called eflornithine), had previously been successful and approved by the Food and Drug Administration to treat other illnesses related to ODC problems. like African sleeping sickness and hirsutism (excessive hair growth). It has also been studied in clinical trials in colon cancer and pediatric neuroblastoma.

In 2018, Caleb Bupp, a medical geneticist at Helen DeVos Children’s Hospital in Grand Rapids and clinical assistant professor in the Department of Pediatrics and Human Development at Michigan State University College of Human Medicine, had an unusual patient. Three-year-old Marley Berthoud’s symptoms included a large head, complete hair loss, poor muscle tone and developmental delays. She couldn’t hold her head up, feed herself, crawl, or communicate.

When Bupp sequenced the Marley exome (the part of the human genome that contains the genetic code to make proteins), he discovered a mutation in his ODC1 gene. Bupp recalled a presentation by Surender Rajasekaran, Pediatric Critical Care Physician to Helen DeVos and Assistant Professor in the Department of Pediatrics and Human Development at Michigan State University College of Human Medicine, and Bachmann about ODC1, and he contacted them. .

The mutation in Marley’s ODC1 gene caused his body to build up a lot of ODC proteins which were building up in his system. Bachmann knew from his previous work that DFMO deactivates ODC proteins.

“We can’t stop his body from building up ODC protein, but we can make the protein inactive,” Bachmann said.

Bupp was encouraged by previous research by Bachmann showing that DFMO was safe and had minimal side effects in patients, especially children. With his family’s approval, Marley began taking DFMO in 2019. This was the world’s first single-patient study approved by the FDA to treat a patient with an ODC1 mutation using DFMO. .

“From the discovery of the syndrome to the patient’s first dose, it took less than two years,” Bachmann said. “It usually doesn’t happen that quickly.”

While Bachmann, Bupp, Rajasekaran, and Berthoud’s family waited to see if DFMO would work, Marley’s symptom list was officially named Bachmann-Bupp syndrome by Online Mendelian Inheritance in Man, an online database. on human genes and genetic disorders.

“It rarely happens,” Bachmann said. “From today, and for many years to come, medical students will learn Bachmann-Bupp syndrome and it all started at MSU.”

Since she started taking DFMO, Marley has made tremendous progress. She has gained muscle tone, which means she can hold her head up, spoon feed, and crawl, but the most visible sign of success has been new hair growth.

“It’s amazing,” Bachmann said. “When I first saw a photo of her, I couldn’t believe she had grown so much hair in a year, and she managed to sled down a hill on her own.”

Seeing all of these external advancements was promising, but Bupp wanted to dig deeper to learn more about the internal changes that occur inside Marley’s body as a result of the DFMO treatment. Bupp contacted Metabolon, a health technology company based in Morrisville, North Carolina, which has developed a tool to detect biomarkers of rare diseases and response to treatment.

Metabolon’s Precision Metabolomics technology could test Marley’s blood samples before and during treatment to find out exactly how his body’s metabolism responded to DFMO treatment and the effect the drug was having on his body.

“There’s not really a regular lab test you can do to look at this, so working with Metabolon has given us a window into Marley’s biochemistry that wouldn’t have been possible otherwise,” said Bupp. “What we saw in the numbers matched what we saw with our eyes – his body was changing inside, too.”

The result of what was going on inside Marley’s body confirmed that the DFMO was working and was just as impressive as what was going on outside.

“Now Marley uses sign language when she couldn’t communicate before,” Bupp said. “My heart melted when she was able to give me a high five for the first time.”

Republished courtesy of Michigan State University. Photo: The patient variant falls on the messy C-terminus of the ODC, where the two active sites are made up of amino acids from each of the two ODC proteins forming a dimer. Credit: eLife 2021; 10: e67097

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Madurai vet rents his bike for baby squirrels to nest https://vetclinpathjournal.org/madurai-vet-rents-his-bike-for-baby-squirrels-to-nest/ https://vetclinpathjournal.org/madurai-vet-rents-his-bike-for-baby-squirrels-to-nest/#respond Tue, 20 Jul 2021 23:40:00 +0000 https://vetclinpathjournal.org/madurai-vet-rents-his-bike-for-baby-squirrels-to-nest/

Express news service

MADURAI: Meril Raj, a resident of Koodal Nagar in Anaiyur, has too often seen a squirrel hanging around on her bicycle. When he opened the hood of his bike saddle he expected to find the cables on his bike askew, but what he actually found was something else entirely.

“A squirrel often came to my bike even though there were trees nearby. At first I was afraid that the squirrel had bit the cables of the bike. But when I opened the hood of my bicycle saddle, I found a nest prepared for the unborn squirrels. I didn’t want to disturb them so I left the bike there and started using the other vehicle, ”he said. Raj, who is an assistant vet, has been letting the squirrels live in his vehicle for a month now.

A few weeks later, Meril found three baby squirrels in his nest on his bicycle. In a video shared with TNIE, the mother squirrel is seen picking up one of the baby squirrels he left on the ground.

“That same night the baby squirrel was brought back to the nest on my bicycle. Squirrels are generally sentient beings. I understood that they felt safe inside the nest than anywhere else. So we decided to let them ride the bike until the three squirrels came out of the nest.

How did the squirrel end up inside the vehicle? Entering the bike from the side and with a little help from the high seat. “It would cost me Rs 5,000 to repair the broken wires on the bike. But it’s all worth it, ”said Meril with delight.

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DVIDS – News – Connecticut National Guard lab technicians train at BJACH https://vetclinpathjournal.org/dvids-news-connecticut-national-guard-lab-technicians-train-at-bjach/ https://vetclinpathjournal.org/dvids-news-connecticut-national-guard-lab-technicians-train-at-bjach/#respond Tue, 20 Jul 2021 20:43:00 +0000 https://vetclinpathjournal.org/dvids-news-connecticut-national-guard-lab-technicians-train-at-bjach/

FORT POLK, Louisiana – The Bayne-Jones Army Community Hospital Pathology Department hosted Connecticut National Guard Sgt. Andrew Meeker for two weeks of hands-on training during his unit’s rotation at the Joint Readiness Training Center and Fort Polk this month. Meeker’s unit, the 142nd Medical Company (Area Support), is at Fort Polk to manage the rear of the JRTC Aid Station and provide medical care to the Arkansas National Guard.

Meeker enlisted in the Guard in 2016 as a combat medic, but was given the opportunity to retrain as a 68K lab technician, in 2020. Meeker said as a member of the National Guard , it is not uncommon for soldiers to have several military professional specialties as needed. of unity, state and army.

Meeker aspires to become a laboratory technician in his civilian career. He hopes the additional training received at BJACH will help him prepare for the American Society of Certified Pathologists exam.

“I joined the military for educational opportunities and to serve my country,” he said. “I started out as a combat medic because I was an emergency medical technician and have always loved first aid, medicine and patient care. This passion evolved into an interest in supporting diagnostic care. I wanted to do more on the investigative side by supporting a doctor’s diagnosis and learning more about the molecular level of things.

Meeker arrived at Fort Sam Houston in January 2020 for his 52-week 68K training where he also completed the clinical practice portion at Brooke Army Medical Center.

“Learning in a lab in the midst of a global pandemic has been incredibly valuable to me,” he said. “As an intern at BAMC I started in the microbiology section and one of the first things I learned was the COVID polymerase chain reaction test on the BioFire and other machines. During my two weeks at BJACH, I took part in several dozen tests.

Meeker said his commanding officer, Major Amanda Griffiths, and the JRTC liaison officer and Fort Polk Command surgeon Major Carmen Salcedo coordinated this additional training at the BJACH lab.

Salcedo said when the 142nd MCAS commander asked if Meeker could get additional training in the lab, she was happy to help.

“The JASR team for this rotation contacted me regarding the Master Sgt. Meeker and asked if he could work in the lab, ”she said. “The Head of Pathology at BJACH was more than accommodating and Staff Sgt. Heather Adkins, our 68K student coordinator, made sure he was able to work on all of his basic skills.

Salcedo said the 142 MCAS is a small, two-roller clinic and has a full complement of medical staff. She said putting Meeker through the lab for two weeks was a unique situation, but she’s always ready to support the National Guard and reserve soldiers who are due to complete their two-week training each summer if she can.

Meeker said the BJACH team had helped him improve his confidence and skills.

“The staff at the BJACH laboratory have been very welcoming,” he said. “I really like hematology, so being able to see the ins and outs of a variety of tests has been interesting. Getting to know all the different departments and getting an overview of operations was a rewarding experience. “

Melissa Hagen, BJACH Blood Bank Supervisor, said Meeker was mutually beneficial for the lab as they could see how someone else was doing things similar or different from the BJACH team.

“Staff sergeant. Meeker did a great job while he was with us, ”she said. “He is very motivated and eager to learn. We will miss having him around.

Date taken: 07/20/2021
Date posted: 07/20/2021 4:43 PM
Story ID: 401327
Location: FORT POLK, LA, UNITED STATES
Hometown: DANBURY, Connecticut, United States

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Strong immune response underlies acute kidney injury linked to COVID-19 https://vetclinpathjournal.org/strong-immune-response-underlies-acute-kidney-injury-linked-to-covid-19/ https://vetclinpathjournal.org/strong-immune-response-underlies-acute-kidney-injury-linked-to-covid-19/#respond Tue, 20 Jul 2021 20:34:56 +0000 https://vetclinpathjournal.org/strong-immune-response-underlies-acute-kidney-injury-linked-to-covid-19/

ROCHESTER, Minn. – Researchers at the Mayo Clinic have found that acute kidney injury associated with COVID-19 resembles kidney injury caused by sepsis, and the immune response triggered by the infection plays a central role.

The conclusions, published in Proceedings of the Mayo Clinic, also suggest that mitochondrial dysfunction – a loss of function in the production of cellular energy – is commonly seen in kidney damage linked to COVID-19. More than a third of hospitalized COVID-19 patients report acute kidney failure, and sudden kidney failure is a risk factor for in-hospital mortality, according to studies published last year.

“These results suggest that COVID-19 may induce a robust immune response in patients that contributes to kidney injury, and kidney supportive treatments should be initiated early for these patients,” says Mariam Alexander, MD, renal pathologist at the Mayo Clinic and the lead author of the study. “Our data indicate that mitochondrial damage is a potential target for therapies, some of which have recently been developed and tested in preclinical models.”

Severe COVID-19 disease is known to be associated with a systemic inflammatory response, as well as inflammation of the heart and lungs. Little research is available on the immune response in the kidneys, and molecular studies on renal pathology in COVID-19 patients have been limited.

“To our knowledge, this is the first comprehensive study examining the molecular and cellular changes observed in kidney damage associated with COVID-19,” said Dr. Alexander.

The Mayo Clinic study evaluated the kidneys of 17 adults who died from COVID-19 and underwent an autopsy in Mayo between April 2020 and October 2020. Researchers described the pathological spectrum of COVID-19-related kidney injury and characterized its molecular profile, relative to injuries associated with sepsis.

According to the study, the morphological and molecular profile of severe kidney damage from COVID-19 resembles kidney damage from sepsis, including microvascular dysfunction, inflammation, and metabolic reprogramming.

“The acute kidney injury seen in COVID-19 is likely secondary to activation of the immune system, similar to what is seen in patients with sepsis,” says Dr. Alexander. “COVID-19 kidneys are inflamed and have an increased rate of cell death, including more mitochondrial damage, compared to kidneys with non-COVID-19 damage.” Mitochondria are cellular structures that generate much of the chemical energy necessary for cells to function properly.

Of COVID-19 patients admitted to hospital intensive care units, 76% have acute kidney failure. According to data published in the Journal of the American Society of Nephrology, COVID-19 hospital patients with secondary acute kidney disease have an almost 50% risk of death, compared to 8% among those without kidney failure.

The 17 patients in the Mayo Clinic study had a median age of 78 and 15 were men. Most had been hospitalized more than five days before death and 53% reported hypertension as a comorbidity. The other main comorbidities included diabetes and cardiovascular disease.

“The complex integrated imaging and molecular tests used in this study pave the way for performing similar molecular analyzes in different diseases to study immune-mediated kidney damage in native and transplant settings,” says Timucin Taner , MD, Ph.D., a Mayo Clinic transplant surgeon, immunologist and senior author. “We currently have several projects using this approach, with the aim of identifying the underlying mechanisms of different diseases, so that we can help doctors treat these conditions more effectively.”

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About Proceedings of the Mayo Clinic

Proceedings of the Mayo Clinic is a peer-reviewed monthly journal that publishes original articles and journals in clinical and laboratory medicine, clinical research, basic scientific research, and clinical epidemiology. Proceedings of the Mayo Clinic is sponsored by the Mayo Foundation for Medical Education and Research as part of its commitment to physician education. The journal has been published since 1926 and has a circulation of 127,000 copies.

About the Mayo Clinic

Mayo Clinic is a non-profit organization committed to innovation in clinical practice, education, and research, and providing compassion, expertise, and answers to all in need of healing. Visit the Mayo Clinic News Network for more information on the Mayo Clinic. For more information on COVID-19, including the Mayo Clinic Coronavirus Map Tracker, which has 14-day forecasts of case trends nationwide, visit the Resource Center Mayo Clinic COVID-19.

Media contact:

Bob Nellis, Mayo Clinic Public Affairs, newsbureau@mayo.edu

Warning: AAAS and EurekAlert! are not responsible for the accuracy of any press releases posted on EurekAlert! by contributing institutions or for the use of any information via the EurekAlert system.

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CBD company founded by veterinarian VETCBD Hemp launches first horse-specific product https://vetclinpathjournal.org/cbd-company-founded-by-veterinarian-vetcbd-hemp-launches-first-horse-specific-product/ https://vetclinpathjournal.org/cbd-company-founded-by-veterinarian-vetcbd-hemp-launches-first-horse-specific-product/#respond Tue, 20 Jul 2021 15:03:00 +0000 https://vetclinpathjournal.org/cbd-company-founded-by-veterinarian-vetcbd-hemp-launches-first-horse-specific-product/

LOS ANGELES–(COMMERCIAL THREAD) – VETCBD Hemp, a cannabis company founded by veterinarians, has announced the launch of its first horse-specific product, a broad-spectrum CBD tincture derived from hemp grown in the United States. The 3000 mg tincture is specially developed for horses using premium American hemp and organic extra virgin olive oil triple tested to support brain function, joint mobility and calmness.

“Our trials have shown that horses can benefit from CBD in the same way we’ve seen dogs and cats benefit, especially for supporting environmental stress and joint mobility,” said Founder and CEO of VETCBD, Dr Tim Shu. “Over the past six years, we’ve applied our veterinary expertise in cannabis and hemp to improve the lives of cats and dogs across the country, and we look forward to doing the same for horses.”

Like all VETCBD products, Equine Tincture is tested by accredited third-party laboratories to ensure safety and quality. By using a broad spectrum hemp extract that contains a combination of synergistic cannabinoids, delivering the benefits of what is known as the “entourage effect”, the tincture can complement the horse’s overall wellness routine.

The product is available for sale on VETCBDHemp.com nationwide, except for those residing in Idaho, South Dakota, Nebraska, and California. Current California law states that horses are classified as “farm animals” under the responsibility of the California Department of Food and Agriculture (CDFA). Therefore, because cannabinoids are not approved for use in cattle by the FDA, the CDFA does not authorize the sale of cannabinoid products for horses in California.

To learn more about VETCBD Hemp Tincture for Equines, please visit: https://vetcbdhemp.com/collections/all-products/products/vetcbd-hemp-tincture-equines.

About VETCBD hemp

VETCBD hemp improves the lives of animals thanks to cannabis. Founded in 2015 by veterinarian and medical cannabis pioneer Dr Tim Shu, VETCBD has become an industry leader with its products formulated by veterinarians and triple tested to improve quality of life. Through its One Fur One program and its partnership with Best Friends Animal Society, VETCBD is committed to helping charities provide better lives for less fortunate animals and make the world a better place for all creatures. To learn more about VETCBD, please visit vetcbdhemp.com.

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