American society – Vet Clin Path Journal http://vetclinpathjournal.org/ Fri, 08 Oct 2021 15:49:21 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://vetclinpathjournal.org/wp-content/uploads/2021/05/cropped-icon-32x32.png American society – Vet Clin Path Journal http://vetclinpathjournal.org/ 32 32 Biden is the first president to mark Indigenous Peoples Day https://vetclinpathjournal.org/biden-is-the-first-president-to-mark-indigenous-peoples-day/ https://vetclinpathjournal.org/biden-is-the-first-president-to-mark-indigenous-peoples-day/#respond Fri, 08 Oct 2021 15:37:00 +0000 https://vetclinpathjournal.org/biden-is-the-first-president-to-mark-indigenous-peoples-day/

WASHINGTON (AP) – President Joe Biden issued the first-ever presidential proclamation of Indigenous Peoples Day on Friday, providing the most significant impetus to date in efforts to refocus the federal holiday celebrating Christopher Columbus towards a peoples appreciation indigenous.

Biden also issued a Columbus Day proclamation on Monday, October 11, which is established by Congress.

“For generations, federal policies have systematically sought to assimilate and displace Indigenous peoples and eradicate Indigenous cultures,” Biden wrote in the proclamation of Indigenous Peoples Day. “Today, we recognize the resilience and strength of Indigenous peoples and the immeasurable positive impact they have had on all aspects of American society.”

In a separate Columbus Day proclamation, Biden praised the role of Italian Americans in American society, but also referred to the violence and damage that Columbus and other explorers of the day wrought on the Americas. .

“Today we also recognize the painful history of the wrongs and atrocities that many European explorers inflicted on tribal nations and indigenous communities,” Biden wrote. “It is a measure of our greatness as a nation that we do not seek to bury these shameful episodes from our past – that we face them honestly, that we bring them to light and do all we can to remedy them. “

It is a break with President Donald Trump’s ardent defense of “fearless heroes” like Columbus in his proclamation of the holiday in 2020.

“Sadly, in recent years radical activists have sought to undermine the legacy of Christopher Columbus,” Trump said at the time. “These extremists seek to replace discussion of his vast contributions with discussions of his failures, his discoveries with atrocities, and his accomplishments with transgressions. “

Copyright 2021 The Associated Press. All rights reserved.

Source link

]]>
https://vetclinpathjournal.org/biden-is-the-first-president-to-mark-indigenous-peoples-day/feed/ 0
ABIONYX Pharma announces positive preclinical results in a uveitis model and launches the strategic development of the first class of biomedicines in ophthalmology based on its bio-HDL https://vetclinpathjournal.org/abionyx-pharma-announces-positive-preclinical-results-in-a-uveitis-model-and-launches-the-strategic-development-of-the-first-class-of-biomedicines-in-ophthalmology-based-on-its-bio-hdl/ https://vetclinpathjournal.org/abionyx-pharma-announces-positive-preclinical-results-in-a-uveitis-model-and-launches-the-strategic-development-of-the-first-class-of-biomedicines-in-ophthalmology-based-on-its-bio-hdl/#respond Thu, 07 Oct 2021 06:57:27 +0000 https://vetclinpathjournal.org/abionyx-pharma-announces-positive-preclinical-results-in-a-uveitis-model-and-launches-the-strategic-development-of-the-first-class-of-biomedicines-in-ophthalmology-based-on-its-bio-hdl/

TOULOUSE, France & LAKELAND, Michigan, October 07, 2021– (BUSINESS WIRE) – Regulatory news:

ABIONYX Pharma (Paris: ABNX) (FR0012616852 – ABNX – PEA PME eligible), a new generation biotechnology company dedicated to the discovery and development of innovative therapies, announces today, after having already obtained an orphan drug designation for CER-001 in the treatment of LCAT deficiency, positive preclinical results in ophthalmology and the launch of a strategic development of the first class of biomedicines of its bio-HDL for the treatment of ocular pathologies.

Positive preclinical results in a uveitis model

Following the positive clinical results which included the disappearance of visual blurring linked to corneal lipid deposits in a patient suffering from an LCAT deficiency, treated under a Temporary Authorization for Use, and the marked improvement in the patient’s visual functions which was still observed after 1 year of follow-up (initial results published exclusively in the scientific journal “Annals of Internal Medicine; follow-up information on file), ABIONYX Pharma carried out preclinical studies in ophthalmology to determine the ocular tolerance of its bio-HDL and the potential spectrum of efficacy in new indications.

Bio-HDL has been shown to be completely safe and very well tolerated on the ocular surface and inside the eye, regardless of the route of administration in a preclinical study, either by intravenous injection, by application of drops on the surface of the eye or by injection inside the eye itself (into the vitreous).

Additionally, bio-HDL has been tested in a proof of concept efficacy study using a recognized and validated preclinical model of uveitis. In this model of endotoxin-induced uveitis (EIU), the uveitis was triggered by a dose of lipopolysaccharide (LPS) injected into the vitreous. Subsequent treatment with CER-001 injected into the vitreous body showed a statistical reduction in signs of uveitis, as measured by protein concentration and cellular infiltration into aqueous humor.

These first preclinical results indicate the major therapeutic potential of bio-HDL in ophthalmology, and more broadly the role of lipids in ocular pathologies.

Dr Christophe Baudouin, professor of ophthalmology in Paris, head of the ophthalmology department at the National Hospital of Ophthalmology of the Quinze-Vingts Hospital (Paris), director of the “S12” research team at the Institut de la Vision , and member of the prestigious international societies, American Society of Ophthalmology and Academia Ophthalmologica Internationalis, states: “The latest scientific work in the field shows that lipids and their metabolism are involved in many eye pathologies, for example meibomian gland dysfunction and macular degeneration. By testing CER-001, a biomimetic HDL produced in France, in models of ocular pathology, we will be able to help choose the best ocular indication for this product, with the aim of offering patients a new effective treatment. “

Development of the first class of biomedicines in ophthalmology with bio-HDL

Following the obtaining of the orphan designation by the European Medicines Agency (EMA) for its drug candidate CER-001 as a potential treatment for LCAT deficiency, ABIONYX Pharma’s bio-HDL is one of the most popular biomedicines. more advanced in France which could soon be marketed in ophthalmology.

As a reminder, there are two forms of LCAT deficiency:

– familial LCAT deficiency (FLD), which results from a complete deficiency and is clinically characterized by hemolytic anemia, renal failure (frequently leading to renal transplantation) and corneal opacities; and

– “Fish Eye Disease” resulting from a partial deficiency and clinically characterized by more severe corneal opacities without renal damage.

As the orphan drug designation obtained covers both a renal indication and an ophthalmologic indication, the clinical development of bio-HDL in ophthalmology can be very rapid.

Lipids are of major interest to the eye in several respects: its structural role, its functional role, its pathophysiological links and its therapeutic potential.

Dr Catherine Creuzot-Garcher, Professor of Ophthalmology in Dijon, Head of the Ophthalmology Department at Dijon University Hospital, University Professor, co-head of the Eye, Nutrition and Cell Signaling team at the Center des Sciences du Goût et de l’Alimentation in Dijon, and Dr Niyazi Acar (PhD), head of the Eye, Nutrition and Cellular Signaling team at the Dijon Center for Taste and Food Sciences, declares: “The study and development of the therapeutic potential of CER-001, a biomimetic HDL, in the treatment of eye diseases will allow us to better understand the role of lipids in the physiology and dysfunctions of the eye, in particular of the retina,” and to offer our patients an innovative solution for the future. “

The anti-inflammatory and / or reverse lipid transport enhancing properties of CER-001, which may improve vision in patients with deficient LCAT activity, combined with new preclinical findings in uveitis, pave the way for studies clinical trials testing bio-HDL in patients developing corneal lipid deposits from other pathologies, and allow ABIONYX Pharma to launch a strategic development of the first class of biomedicines in ophthalmology based on its bio-HDL.

About ABIONYX Pharma

ABIONYX Pharma is a new generation biotechnology company that aims to contribute to health through innovative therapies in indications where there is no effective or existing treatment, even the rarest. Thanks to its partners in research, medicine, biopharmaceuticals and shareholders, the company innovates on a daily basis to offer drugs for the treatment of kidney and ophthalmological diseases, or new HDL vectors used for targeted drug delivery.

See the source version on businesswire.com: https://www.businesswire.com/news/home/20211006006078/en/

Contacts

NewCap
Investor Relations
Louis-Victor Delouvrier
abionyx@newcap.eu
+33 (0) 1 44 71 98 53

NewCap
Media relations
Nicolas merigeau
abionyx@newcap.eu
+33 (0) 1 44 71 94 98

Source link

]]>
https://vetclinpathjournal.org/abionyx-pharma-announces-positive-preclinical-results-in-a-uveitis-model-and-launches-the-strategic-development-of-the-first-class-of-biomedicines-in-ophthalmology-based-on-its-bio-hdl/feed/ 0
Sports Illustrated Dubs Trae Young and Luka Doncic Generation Next NBA Leaders https://vetclinpathjournal.org/sports-illustrated-dubs-trae-young-and-luka-doncic-generation-next-nba-leaders/ https://vetclinpathjournal.org/sports-illustrated-dubs-trae-young-and-luka-doncic-generation-next-nba-leaders/#respond Wed, 06 Oct 2021 19:37:00 +0000 https://vetclinpathjournal.org/sports-illustrated-dubs-trae-young-and-luka-doncic-generation-next-nba-leaders/

NEW YORK–(COMMERCIAL THREAD) – Three years ago, Trae Young and Luka Doncic were traded on draft night. Now their connection runs deeper: They lead a wave of young superstars who will shape the future of the NBA while pushing their teams to new heights. In the NBA and College Basketball Preview issue, available online today and on shelves October 14, lead writers Michael Pina and Michael Shapiro take a deeper look at the Hawks point guard and the lifeblood of the Mavericks franchise. Also in this issue, Alex Prewitt on Black Widow’s Professional Pool Course, Michael Rosenberg on Penny Hardaway’s Ascendant Basketball Program in Memphis, Q&A with Halle Berry on his new Jon MMA movie Wertheim, and more.

NBA preview features

  • The future is now: Trae Young and Luka Doncic are at the forefront of NBA’s Generation Next, a wave of young stars who will shape the future of the league. Michael Pina and Michael Shapiro explore how they are reshaping the NBA in their image.
  • The trick: The dynasties are dead and the NBA title is entirely up for grabs, according to lead writer Howard Beck. Pluses: three sneakers to watch this season and SI Sportsbook’s picks and odds for NBA awards races. Don’t miss either Jeremy Woo’s large NBA Draft 2022 chart and a summary of this year’s banned offensive moves.
  • The rebound: Karl-Anthony Towns has lost seven family members to COVID and spent last season trying to find closure after a year of tragedy. Now the centerpiece of the Timberwolves is ready to move forward, details Michael Pina.
  • Scouting Reports: SI breaks down every division of the NBA’s intriguing matrix – who’s good, who isn’t, and who’s fascinating no matter what. Plus, the final prediction: The Lakers over the Nets.

College basketball preview features

  • Inverted pyramid: Michael Rosenberg examines Memphis, America’s most interesting program – led by coach Penny Hardaway, two of the nation’s top rookies (Emoni Bates and Jalen Duren) and a team including NBA coaching legend Larry Brown and the ‘Former All-Star Rasheed Wallace.
  • The Top 20: Emma Baccellieri and Elizabeth Swinton project the best women’s teams in the country, and Kevin Sweeney faces the men.

Also in this issue:

  • Black Widow – You know Jeanette Lee as the once brash face of ’90s billiards. Alex Prewitt reveals that after being diagnosed with cancer, she embarks on self-discovery and enjoys the little things in life.

  • How long can we play? From NFL legends to pickup races at the YMCA, we all give in to the urge to compete later in life. Here’s why the push to extend athletic immortality isn’t just for Brady and LeBron anymore, by Chris Ballard.

  • A photographic look at five rookie quarterbacks who, for better or worse, defined the first month of the NFL season.

  • Steve Rushin on a consequence of the new 17-game NFL season: the death of the .500 team.

  • Jon Wertheim Q&A with Halle Berry, director and star of the new MMA-themed film, “Bruised”.

  • The mystery of the first LA Rams helmet, by Greg Bishop.

Subscribe today for the best storytelling in sports or buy unique issues to sell. To schedule a broadcast or print interview, contact SI at media@maven.io.

About Sports Illustrated

Sports Illustrated (SI) is an unprecedented and influential leader recognized for shaping modern culture and uniting athletes, teams and fans around the world. SI’s award-winning media company brings powerful storytelling to life on platforms ranging from award-winning video to Emmy to the monthly print magazine with a 67-year legacy. Get in-depth features, poll profiles, and iconic and beloved photography from the game’s top writers and photojournalists at SI.com. In July, the American Society of Magazine Editors announced that SI had won the award for Best Sports and Fitness Coverage in its 2021 contest with “Empty Arena.”

About the Arena group

The Arena Group, formerly Maven, creates robust digital destinations that thrill consumers with experiences, powerful journalism, and news about the things they love – their favorite sports teams, investment advice, the scoop on personal finance and the latest essential lifestyle information. With superior technology, editorial expertise and marketing know-how, the modern media business enables brands like Sports Illustrated and TheStreet to deliver highly relevant content and experiences that consumers love. To learn more, visit www.thearenagroup.net.

Source link

]]>
https://vetclinpathjournal.org/sports-illustrated-dubs-trae-young-and-luka-doncic-generation-next-nba-leaders/feed/ 0
New Doctors | Mercy Health Services – Maryland Daily Record https://vetclinpathjournal.org/new-doctors-mercy-health-services-maryland-daily-record/ https://vetclinpathjournal.org/new-doctors-mercy-health-services-maryland-daily-record/#respond Wed, 06 Oct 2021 04:39:23 +0000 https://vetclinpathjournal.org/new-doctors-mercy-health-services-maryland-daily-record/

Merciful health services recently added eight new physicians to its practices throughout the Baltimore area.

Jeffrey Yang, MD, has joined the radiology department of Mercy Health Services. He is eligible for the Board of Trustees and received his medical degree from the University of Buffalo School of Medicine and Biomedical Services in Buffalo, New York. He completed his internship in internal medicine at Mercy Medical Center and his residency in diagnostic radiology at Icahn School of Medicine at Mount Sinai in New York, New York. He received a Fellowship in Neuroradiology from the Johns Hopkins University School of Medicine in Baltimore. During his studies and training in medicine, Yang participated in many research projects and is the author of several medical publications. He has also received numerous awards and honors for research excellence. Yang is a member of several professional organizations, including the American College of Radiology and the American Society of Neuroradiology.

Ashley Wade-Vuturo, MD, joined the OB / GYN Hoffman and Associates practice of Mercy Health Services. Wade-Vuturo is an OB-GYN providing gynecological care for women from adolescence to post-menopause. She specializes in routine and complex obstetric care, including patients diagnosed with diabetes and other chronic diseases. Wade-Vuturo received his medical degree from the University of Maryland School of Medicine in Baltimore and completed his residency at the University of Maryland Medical Center in Baltimore.

Evelyn A. May, MD, joined the Tyanna O’Brien Center for Women’s Imaging at Mercy Medical Center in Baltimore. May, a diplomat with the American Board of Radiology, received her medical degree from Pontificia Universidad Catolica de Chile in Santiago, Chile, where she also completed her radiology residency program and graduated Summa Cum Laude. . She completed her clinical training in breast imaging and pediatric radiology in the Russell H. Morgan Department of Radiology and Radiologic Science, Johns Hopkins University School of Medicine. May was a breast imaging specialist in various medical institutions as well as an assistant professor of radiology in the Russell H. Morgan Department of Radiology and Radiological Science at Johns Hopkins University School of Medicine. She is currently editor of the American Journal of Roentegenology, a monthly journal published by the American Roentgen Ray Society.

Emily A. Wisniewski, MD joined Mercy Family Care Physicians and Mercy Health Services. She is a pediatrician specializing in the care of children from infancy to adolescence. Wisniewski provides care to children dealing with a wide range of conditions and disorders. She diagnoses and treats common childhood illnesses such as ear infections, allergies and the common cold, as well as chronic illnesses such as diabetes and asthma. Wisniewski received his medical degree from the University of Maryland School of Medicine and completed his residency at the University of Maryland Medical Center in Baltimore.

Assistant physician Jamie Sabo, PA-C joined Mercy Personal Physicians at Overlea and Mercy Health Services. Sabo works in partnership with the doctor of internal medicine Dr Christina Gasbarro. Sabo provides primary care services to patients 18 years of age and older. She diagnoses and treats a variety of acute and chronic conditions such as colds and flu as well as diabetes, high blood pressure and heart disease. Sabo also offers vaccinations, wellness treatments and routine physical exams. Sabo holds a Bachelor of Science in Public Policy from the University of North Carolina at Chapel Hill and a Master of Science in Medical Assistant Studies from the University of South Carolina School of Medicine. in Columbia, South Carolina. She is a member of the American Academy and the Maryland Academy of Physician Assistants.

Jehan Riar, MD joined Mercy Personal Physicians in Lutherville and Mercy Health Services. She provides primary care to patients aged 18 and over. She diagnoses and treats a variety of acute and chronic conditions and offers wellness exams, annual vaccinations, and routine physical exams. Riar is particularly interested in the treatment of patients who suffer from anxiety and depression. She is also passionate about providing healthy female care for patients 40 years of age and older. Riar received his medical degree from St. Matthew’s University School of Medicine in Grand Cayman and completed his residency at St. Louis University School of Medicine in St. Louis.

Adam J. Schell, MD joined the Maryland Spine Center and Mercy Health Services. Schell is a bursary-trained orthopedic spine surgeon. It provides comprehensive care and treatment for common and complex spinal disorders. He completed his residency and internship in orthopedic surgery at Case Western Reserve University School of Medicine in Cleveland, Ohio. He obtained his Orthopedic Spine Fellowship at the prestigious Emory University School of Medicine in Atlanta, where he also obtained his medical degree. Schell is a member of the Alpha Omega Alpha Honor Society, the American Academy of Orthopedic Surgeons, the North American Spine Society, and the American Orthopedic Association’s Emerging Leaders program.

Gynecologist Jeri shuster, MD, joined the Mercy Physicians Institute for Gynecological Care in Colombia. Shuster is board certified in Obstetrics and Gynecology. She is particularly interested in menopause, as well as patients with conditions such as osteoporosis and hormone replacement therapy. Shuster received his undergraduate and medical degrees from George Washington University in Washington. She completed her residency in Obstetrics and Gynecology at the University of Maryland Medical Center. Shuster is a graduate of the American College of Obstetricians and Gynecologists, Fellow of the American Council of Obstetrics and Gynecology, Certified Clinical Densitometrist, Fellow of the International Society for Clinical Densitometry, the National Osteoporosis Foundation, and the North American Menopause Society.

Source link

]]>
https://vetclinpathjournal.org/new-doctors-mercy-health-services-maryland-daily-record/feed/ 0
Isatuximab-irfc (Sarclisa) for relapsed / refractory multiple myeloma https://vetclinpathjournal.org/isatuximab-irfc-sarclisa-for-relapsed-refractory-multiple-myeloma/ https://vetclinpathjournal.org/isatuximab-irfc-sarclisa-for-relapsed-refractory-multiple-myeloma/#respond Tue, 05 Oct 2021 13:54:07 +0000 https://vetclinpathjournal.org/isatuximab-irfc-sarclisa-for-relapsed-refractory-multiple-myeloma/ Isatuximab-irfc (Sarclisa; sanofi-aventis) offers patients another treatment option and significantly reduces the risk of disease progression or death.

Isatuximab-irfc (Sarclisa; sanofi-aventis US LLC) is a targeted monoclonal antibody approved for patients with relapsed and refractory multiple myeloma, the second most common cancer of the blood.1.2

More than 130,000 Americans are affected by multiple myeloma and approximately 32,000 patients are diagnosed each year.1 Most patients will relapse because the multiple myeloma is incurable.3

Indications and dosage

Isatuximab is used in combination with pomalidomide (Pomalyst; Celgene) and dexamethasone (IPd) in patients who have received at least 2 previous treatments, including lenalidomide and a proteasome inhibitor.4 Isatuximab is also indicated in combination with carfilzomib (Kyprolis; Amgen) and dexamethasone (IKd) in patients who have received 1 to 3 previous lines of treatment.4

The recommended dose of isatuximab is 10 mg / kg, using actual body weight, as an intravenous (IV) infusion.4 Healthcare professionals give the infusion weekly for 4 weeks in cycle 1 (days 1, 8, 15 and 22), then every 2 weeks in cycle 2 (days 1, 15 and beyond), until ‘to disease progression or unacceptable toxicity.4 The first 2 infusions last 3 to 4 hours, but the remaining infusions last approximately 75 minutes.2

Action mechanism

Isatuximab works in 3 ways:2.5

  1. Finds and binds to cell surface protein CD38 (widely expressed on myeloma cells), exposing them to elimination by the immune system.
  2. Strengthens the immune system, which makes it harder for myeloma cells to survive.
  3. Directly kills myeloma cells.

FDA approval

The FDA first approved IPd in ​​March 2020 based on data from the ICARIA-MM Phase 3 clinical trial.2.4 Progression-free survival (PFS) was the main measure of effectiveness.2 The researchers found a 40% reduction in the risk of disease progression or death (p = 00010).1.2

The second approval in March 2021 was based on IKEMA’s efficacy and safety trial using IKd.3.4 The researchers found a 45% reduction in the risk of disease progression or death (p = 0.0032).3.4

Adverse reactions (AEs)

The most common AEs are neutropenia, upper respiratory tract infections (including pneumonia), infusion-related reactions, and diarrhea.2.4

Healthcare providers periodically monitor neutrophil counts and may give granulocyte colony stimulating factor to increase white blood cell production.2 Antibiotics or antivirals can help prevent infection.1

Providers manage infusion reactions with premedication using dexamethasone, acetaminophen, H2 antagonists and diphenhydramine (see Table 1).4

Premedications are given 15 to 60 minutes before the start of the isatuximab infusion.4 Reactions may require healthcare professionals to slow or stop the infusion, or to stop treatment with isatuximab completely.1

Patients should prevent dehydration caused by diarrhea by drinking enough water.2 The American Society of Clinical Oncology recommends that patients receiving cancer treatment drink at least 8 cups of water each day.6

Unique to IKd, common AEs include fatigue, hypertension, dyspnea, insomnia, bronchitis, cough, and back pain.4

In addition, patients treated with isatuximab are at risk of new primary cancers (the overall incidence is 3.6%).4 Patients may develop heart failure during treatment with IKd.4 Changes in blood tests can occur and affect blood group results.4

Isatuximab binds to CD38 on red blood cells (RBCs) and may result in a false positive indirect antiglobulin test (indirect Coombs test). Blood banks can resolve this interference with blood compatibility tests by using red blood cells treated with dithiothreitol.4

Pregnancy and breast feeding

Isatuximab is contraindicated in pregnant women and may harm the unborn child.4 Breast-feeding women should not breast-feed during treatment.4 Pharmacists should advise patients of childbearing potential to use contraception during treatment and for at least 5 months after the last dose.4

THE REFERENCES

1. FDA approves Sarclisa (isatuximab-irfc) for patients with relapsed multiple myeloma [News release]. sanofi-aventis US LLC. March 2, 2020. Accessed July 16, 2021. https://www.sanofi.com/en/media-room/press-releases/2020/2020-03-02-19-51-16

2. Understand the SARCLISE. International Myeloma Foundation. Published June 2020. Accessed July 15, 2021. https://imf-d8-prod.s3.us-west-1.wasabisys.com/2020-06/U-Sarclisa.pdf

3. FDA approves Sarclisa (isatuximab) in combination with carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma [News release]. sanofi-aventis US LLC. March 31, 2021. Accessed July 16, 2021. https://www.sanofi.com/en/media-room/press-releases/2021/2021-03-31-23-15-00-2202919

4. Sarclisa. Prescribing information. sanofi-aventis US LLC; 2021. Accessed July 15, 2021.

5. How does Sarclisa work. sanofi-aventis US LLC. Updated June 2021. Accessed July 16, 2021. https://www.sarclisa.com/how-sarclisa-works

6. The importance of hydration. American Society for Clinical Oncology (ASCO). July 1, 2009. Accessed July 17, 2021. https://www.cancer.net/blog/podcasts/importance-hydration

Source link

]]>
https://vetclinpathjournal.org/isatuximab-irfc-sarclisa-for-relapsed-refractory-multiple-myeloma/feed/ 0
Challenging the “No Food After Midnight Before Surgery” Rule | Lifestyles https://vetclinpathjournal.org/challenging-the-no-food-after-midnight-before-surgery-rule-lifestyles/ https://vetclinpathjournal.org/challenging-the-no-food-after-midnight-before-surgery-rule-lifestyles/#respond Mon, 04 Oct 2021 22:23:00 +0000 https://vetclinpathjournal.org/challenging-the-no-food-after-midnight-before-surgery-rule-lifestyles/

OF THE NORTH AMERICAN UNION, 300 W 57th STREET, 15th FLOOR, NEW YORK, NY 10019

CUSTOMER SERVICE: (800) 708-7311 EXT. 236

TO YOUR GOOD HEALTH # TFB20211015

FOR PUBLICATION OCT WEEK. 11, 2021 (COL. 5)

BY LINE: By Keith Roach, MD

DEAR DR. ROACH: Why is it that no matter what time a surgery is scheduled, the rule is “no food or drink after midnight”? My recent intervention was scheduled for 12:30 p.m. I was told I couldn’t eat after midnight. My procedure would take two hours and the recovery took two hours. It’s more than 16 hours without eating! When I told the planner that I would have a sick headache from not having food for 16 hours, I was told that was the policy. Period. No food after midnight. “Besides,” she said, “they will give you food while you are recovering.”

Well, I’m sorry, but a bathroom cup-sized glass of juice and crackers has no effect. It is too late then. And as it happened, they didn’t give me anything in recovery anyway. I ate on the way home, but was sick for hours. If my operation had been scheduled for 6 am it would have been 10 am without food. At noon, 4 p.m. without food. Etc. Why the one-size-fits-all policy? The feeding cut-off time should be adapted to the time of surgery. Maybe midnight is just an easy time to remember. – Mo

ANSWER: I agree with you that 16 hours without food is both cruel and unnecessary and can actually lead to harm, such as worsening postoperative nausea and vomiting. Even 10 hours is more than necessary. The American Society of Anesthesiologists, like most expert societies, recommends that adults refrain from eating heavy food (including fat and meat) eight hours before surgery; fast on any solid food or milk six hours before surgery; and fasting of clear fluids two hours before surgery.

In your case, with a procedure scheduled for 12:30 pm, you could certainly have woken up early (say 6:00 am) and had a light breakfast; then had water, black coffee or tea until 10:30 am. I can’t say why your surgical center was so dogmatic.

Of course, some people can have medical conditions that require longer periods of fasting, so you should ask your surgeon or anesthesiologist what and when to eat.

DEAR DR. ROACH: My recent echocardiogram indicated that I had 50% heart function, which my doctor said was “weakly normal”. I’m a 74 year old male who exercises two to three times a week on a treadmill, spending 45 minutes at 3.5 mph covering 2.6 miles. Can exercise increase heart function, or once it’s gone, it’s gone? – MC

ANSWER: The ejection fraction is a unique measure of heart function taken by an echocardiogram. It measures the amount of blood ejected from the left ventricle during each cardiac cycle. The normal range is 50-75%, but 75% is not necessarily better. A very high ejection fraction is not normal. A low ejection fraction is common: about 12% of people will have an EF below 54%. A level below 45% is usually associated with symptoms of heart failure. However, elite athletes often have low normal to normal ejection fractions.

What is more important than any heart measurement is what you are able to do. You train pretty well. It is likely that if you increase your speed, you will gradually get used to a higher speed as your heart function improves. Exercise can improve heart function in almost anyone.

* * *

Dr Roach regrets not being able to respond to individual letters, but will fit them into the column whenever possible. Readers can send questions by email to ToYourGoodHealth@med.cornell.edu or by mail to 628 Virginia Dr., Orlando, FL 32803.

(c) 2021 North America Syndicate Inc.

All rights reserved

Source link

]]>
https://vetclinpathjournal.org/challenging-the-no-food-after-midnight-before-surgery-rule-lifestyles/feed/ 0
Supplements to prevent bone fractures? VITAL says forget it https://vetclinpathjournal.org/supplements-to-prevent-bone-fractures-vital-says-forget-it/ https://vetclinpathjournal.org/supplements-to-prevent-bone-fractures-vital-says-forget-it/#respond Sun, 03 Oct 2021 23:30:55 +0000 https://vetclinpathjournal.org/supplements-to-prevent-bone-fractures-vital-says-forget-it/

New analyzes from the large prospective study called VITAL cast further doubt on the value of routine vitamin D and omega-3 fatty acid supplements for generally healthy individuals.

Daily administration of 2,000 IU of vitamin D, in many cases in addition to the supplements the study participants were taking themselves, had no effect on fracture risk for about 5 years, said Meryl LeBoff, MD, of Brigham and Women’s Hospital, Boston, at the American Society for Bone and Mineral Research (ASBMR) Annual Meeting held online and in San Diego.

With an almost equal number of participants receiving vitamin D compared to placebo, the number of incident fractures of all types was also almost equal, at 769 versus 782, for a risk ratio of 0.98 (95% CI 0 , 89-1.08), said LeBoff. The numbers were also very similar between the groups for non-vertebral fractures and hip fractures.

And two other sub-studies of VITAL, both presented as “electronic posters” to ASBMR by Sharon Chou, MD, also of Brigham and Women’s, found no benefit of omega-3 supplements over participants’ physical abilities or bone health biomarkers.

This is just the example of a rigorous randomized trial contradicting anecdotal and observational reports that supplements have significant preventative effects.

VITAL, you may remember, randomized some 25,000 generally healthy people, of which about 20% were black, in a 4 × 4 design to double the placebo, 2,000 IU / day of vitamin D3, 1000 mg / day of omega-3 capsules, or both supplements. The median follow-up was just over 5 years. Cancer and cardiovascular events were the predefined primary outcomes (for which there was no benefit), but the design included additional substudies to examine other putative effects of these supplements.

Of particular interest is the new analysis of fracture rates in VITAL because, of all the claimed benefits for vitamin D, bone health is the strongest evidence. The current government recommendation of 400 IU per day is based on studies indicating that vitamin D is needed to maintain bone integrity.

But whether supplementation at 2,000 IU per day in addition to normal sources – food intake and sun exposure – provides additional protection was less clear.

VITAL recruited a relatively unselected group of men (aged 50 and over) and women (aged 55 and over) to receive daily vitamin D and / or omega-3 supplements as part of the double-blind, double-sham, placebo-controlled study. The relatively young age of the participants (average 67) was a point of interest for at least one member of LeBoff’s audience, who questioned whether the results were relevant to older people, for whom the risk of fracture is highest.

“We can’t generalize to people in their 80s,” LeBoff admitted.

And vitamin D advocates may well be critical of other aspects of the trial, such as dosing (7,000 IU / day or more is often recommended) and target levels of vitamin D in the blood.

But the results were also reinforced by the rigorous judgment of the fractures. LeBoff pointed out that the supplements were very effective in increasing blood levels of the active vitamin D metabolite, 25- (OH) D, with most participants receiving the active product reaching levels of at least 40 ng / mL. (Levels of 30 ng / mL have traditionally been considered adequate for bone health.)

In addition, fracture rates were similar among groups of participants defined by baseline levels (<20, 20-29 or ≥30 ng / mL).

In poster presentations, Chou and his colleagues explained that bone benefits have also been claimed for omega-3 fatty acids, with animal studies indicating “increased absorption of calcium, decreased urinary calcium excretion, and reduced urinary calcium excretion. reduction of inflammation and bone resorption “.

They sought to examine the issue in a VITAL subgroup, made up of participants from the New England area who were brought in for imaging tests and physical exams. No signs of the alleged benefits were seen. Measurements of overall bone mineral density and at key locations, bone strength, cortical thickness, and polar stress resistance index were all similar in participants receiving the active supplements compared to placebo.

The same goes for physical abilities, as measured by tests of grip strength, walking speed, sitting, balance and other objective assessments of performance.

  • John Gever was editor-in-chief from 2014 to 2021; he is now a regular contributor.

Disclosures

VITAL was funded by the NIH.

Source link

]]>
https://vetclinpathjournal.org/supplements-to-prevent-bone-fractures-vital-says-forget-it/feed/ 0
Parents: Capital region needs more inclusive playgrounds https://vetclinpathjournal.org/parents-capital-region-needs-more-inclusive-playgrounds/ https://vetclinpathjournal.org/parents-capital-region-needs-more-inclusive-playgrounds/#respond Sun, 03 Oct 2021 04:41:35 +0000 https://vetclinpathjournal.org/parents-capital-region-needs-more-inclusive-playgrounds/

An international company that tests the accessibility and safety of surface materials under playgrounds is expected to issue new guidelines this week.

The measures proposed by the American Society for Testing and Materials are then benchmarked by the Access Board, which in turn sets the standards for compliance with the Americans With Disability Act, said Bill Botten, training coordinator at the US Access Board. .

Botten’s specialty is the issues surrounding recreational facilities and outdoor spaces. Botten said the standards created by the Access Council help communities build accessible play areas.

But these are only the minimum, he said.

“You can meet the accessibility requirements of federal law – it’s easy,” Botten said.

However, Botten, who uses a wheelchair, said being accessible doesn’t necessarily mean being inclusive and meeting the needs of people with different abilities.

“When I think of inclusiveness, I think beyond what we need,” he said.

He said the best way to understand what it means for building a playground is to speak with the people who will be using it and the disability rights groups that are in the area.

This is what Milton resident Krystyn LaBate did as she worked on the construction of an inclusive playground located inside Burgess Kimball Memorial Park.

LaBate’s son, Giovanni, suffers from a cortical malformation and a head disorder, two neurological conditions that partially weakened him. She said that when Giovanni was about 3 years old, she tried to take him to other parks to play, but found it very difficult to cross the playground because of the wood chips, which came together. wedged in his suspenders. Using the equipment wasn’t much easier either, she said.

“It just wasn’t an area he could play in,” she said.

So she decided to contact the city to build a more mobility-friendly playground with an assortment of other play options for children of all skill levels. But before deciding which items to have, she got the others involved.

“In fact, I contacted several families in the area to see what they wanted,” she said.

She has also worked with the company Gametime, which uses Me2: 7 Principles of Inclusive Playground Design to build its structures. These principles, which touch on topics ranging from flexibility of access and inclusion of ramps to equitable opportunities for all children, such as inclusion of sensory objects, were developed by researchers, architects and gaming experts from the Utah State University Center for Person with Disabilities.

“There are a lot of features in this playing field,” LaBate said.

Some include swings with extra support and a chair that moves side to side and back and forth that someone can sit on while others move them.

Wilton’s Becky Manning helped raise funds to create Kaitlin’s Korner in Gavin Park.

Manning had grown up going to Gavin Park, but his daughter, who had a seizure at age 3 and struggled with mobility afterward, struggled to access the park elements.

“There was nothing in that area that gave it that aspect of security,” she said.

So Manning decided the park needed to become more inclusive, and she used $ 106,000 of the money she raised to add items like a seesaw with bucket seats to which additional safety straps could be attached, sensory items like bongo drums that anyone can play with and transition steps to help kids access the jungle gym more easily. Part of the playground has also been given a new floor space similar to what one might see on a track to allow people in wheelchairs to move around better.

“You can’t push a wheelchair over wood chips,” she said.

In Schenectady County, the Central Park playground was revamped a few years ago to include more options for kids, from the spongy ground surface that a wheelchair can easily roll on to ramps. to access the jungle gym containing the slide.

A new playground at Maalwyck Park offers some inclusive swings and a merry-go-round.

Michelle Boyle of Colony enjoys bringing her kids to Cook Park, which she says offers a variety of inclusive items for kids to play with. She said her children especially like the swings that she can ride with them.

She said some of her main items for making a park inclusive are equipment for children who lack core strength or items where children can climb directly into their wheelchairs or walkers.

When places don’t take into account all abilities, they limit who can use their playgrounds, Manning said.

“Every child should be able to enjoy the stimulation, fun and interaction that a play area offers,” she said. “We need more places for children to play together without differences or limits.”

Journalist Shenandoah Brière can be reached at 518-478-3320 or [email protected]

More from The Daily Gazette:

Categories: News

Source link

]]>
https://vetclinpathjournal.org/parents-capital-region-needs-more-inclusive-playgrounds/feed/ 0
North Carolina board adopts strict rules for teaching running https://vetclinpathjournal.org/north-carolina-board-adopts-strict-rules-for-teaching-running/ https://vetclinpathjournal.org/north-carolina-board-adopts-strict-rules-for-teaching-running/#respond Sat, 02 Oct 2021 14:07:27 +0000 https://vetclinpathjournal.org/north-carolina-board-adopts-strict-rules-for-teaching-running/

RALEIGH, NC (AP) – A North Carolina school board adopted a policy preventing critical race theory in its classrooms after county commissioners threatened withholding nearly $ 8 million in funding.

The Johnston County School Board unanimously approved an updated policy on how history and racism will be taught on Friday, The News & Observer of Raleigh reported. Under the new policy, teachers could be disciplined or fired for teaching that historical American figures were not heroes, undermining the U.S. Constitution in class, or portraying racism as a permanent part of American life.

The all-Republican Johnston County board of commissioners was withholding $ 7.9 million until the school board passed a policy banning critical race theory in local classrooms.

A revised code of ethics policy includes new wording such as “the founding documents of the United States must not be undermined” and “all those who have contributed to American society will be recognized and portrayed as reformists, innovators. and heroes of our culture ”.

April Lee, president of the Johnston County Association of Educators and grade eight social science teacher, said the school system “was selling our souls to the devil for $ 7.9 million.” She also said the new policy is “basically extortion”.

Last month, Democratic North Carolina Governor Roy Cooper vetoed a bill that would have limited the way public school teachers can discuss certain racial concepts.

Source link

]]>
https://vetclinpathjournal.org/north-carolina-board-adopts-strict-rules-for-teaching-running/feed/ 0
Fredericksburg Parks Service Retired Chief Historian Helped Bring Mission and Message Changes | Local News https://vetclinpathjournal.org/fredericksburg-parks-service-retired-chief-historian-helped-bring-mission-and-message-changes-local-news/ https://vetclinpathjournal.org/fredericksburg-parks-service-retired-chief-historian-helped-bring-mission-and-message-changes-local-news/#respond Fri, 01 Oct 2021 23:30:00 +0000 https://vetclinpathjournal.org/fredericksburg-parks-service-retired-chief-historian-helped-bring-mission-and-message-changes-local-news/

He noted that one of the remarkable things about America is the reconciliation that took place after the Civil War.

“Nations that experience civil wars do not raise statues to losers, and not only have we tolerated the presence of the vanquished among us, but we have adopted some of them, like Jackson and Lee, as national heroes,” did he declare. . “What we are seeing now in our country is a disentangling of that national identity from the elements that were built on the legacy of Confederation, and it is a painful process.”

He said that traditionally many Americans have had a very personal relationship with the Civil War.

“If you listen intently to the conversations about the Civil War and the people struggling to reconcile the South’s quest to maintain slavery, the default refuge is the staff,” he said. “People are starting to talk about a relative, a great-grandfather from the Shenandoah Valley. And they point out that he didn’t own any slaves, but fought for the South, so obviously the war wasn’t about slavery.

Hennessy noted that he had no problem admiring the bravery and sacrifice of those who fought for the South, as he does for those who fought for the Union, and understanding why the two have did what they did.

“The only thing to celebrate about the Civil War is the fact that the nation survived intact; that 4 million were freed by war – the bloodiest emancipation in the history of the world – and that millions more would be born free who were not. And it’s a good thing.

Source link

]]>
https://vetclinpathjournal.org/fredericksburg-parks-service-retired-chief-historian-helped-bring-mission-and-message-changes-local-news/feed/ 0