American society – Vet Clin Path Journal Sat, 25 Jun 2022 11:04:16 +0000 en-US hourly 1 American society – Vet Clin Path Journal 32 32 How the Christian Right Seized Judiciary and Changed America | Abortion Sat, 25 Jun 2022 09:33:00 +0000

Jhe Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization, which struck down the constitutional abortion rights enjoyed by American women for the past 50 years, surprised many voters. A majority, after all, support reproductive rights and see their abolition as regressive and barbaric.

Understood in the context of the movement that created the Supreme Court in its current incarnation, it is however not surprising. In fact, it marks the beginning rather than the end of the agenda this movement has in mind.

At the heart of Dobbs is the belief that the power of government can and should be used to impose a certain moral and religious vision – a supposedly biblical and regressive understanding of the Christian religion – upon the general population. .

How could this conviction be so influential in the courts, given the long-standing American principle of separation of church and state? To understand why this is happening now, it is important to know something about the history of the Christian nationalist movement, how its leaders chose the abortion issue as a way to create single-issue voters, and how they united conservatives across denominational barriers in, in effect, inventing a new, intensely political form of religion.

Christian nationalists often claim their movement began as a grassroots reaction to Roe vs. Wade in 1973. But the movement actually gelled several years later with crucial help from a group calling itself the “New Right.” .

Phyllis Schlafly leads a crowd demonstrating against the Equal Rights Amendment in 1976. Photography: Bettmann Archive

Paul Weyrich, Howard Phillips, Phyllis Schlafly and other leaders of this movement were unhappy with the direction of the Republican Party and the culture in general. “We are radicals who want to change the existing power structure. We are not conservatives in the sense that conservative means accepting the status quo,” said Paul Weyrich. “We want change – we are the forces of change.

They were angry with liberals, who they said threatened to undermine national security with their softness on communism. They were angry with the establishment conservatives – the “Rockefeller Republicans” – for siding with the liberals; they were angry with the rising tide of feminism, which they saw as a threat to social order, and with the civil rights movement and the danger it posed to segregation. One thing they were not particularly angry with, at least initially, the issue of abortion rights.

New Right leaders formed common cause with a handful of conservative Catholics, including George Weigel and Richard John Neuhaus, who shared their concerns and attracted powerful conservative preachers such as Jerry Falwell and Bob Jones Sr. They were determined to trigger hyperconservation. counter-revolution. All they needed now was an issue that could be used to unify its disparate elements and draw in the base.

Among their main concerns was fear that the Supreme Court would end tax exemptions for segregated Christian schools. Jerry Falwell and many of his fellow white ministers and southern conservatives were closely involved with segregated schools and universities – Jones went so far as to call segregation “God’s established order” and called desegregationists “satanic propagandists who “leaded Christians of color.” astray.” As far as these pastors were concerned, they had the right not only to separate people on the basis of race, but also to receive federal money for this purpose.

Paul Weyer
Paul Weyrich, a central figure unhappy with the leadership of the Republican Party. Photography: John Preito/Denver Post/Getty Images

They knew, however, that “stop the tax on segregation!” was not going to be an effective rallying cry for their new movement. As historian and author Randall Balmer wrote: “It was not until 1979, six years after Deer – that evangelical leaders, at the behest of conservative activist Paul Weyrich, seized on abortion not on moral grounds, but as a rallying cry to deny President Jimmy Carter a second term. Why? Because the anti-abortion crusade was more palatable than the real motive of the religious right: to protect segregated schools.

In many ways, abortion was an unlikely choice, because when the Roe v Wade decision was handed down, most Protestant Republicans supported it. The Southern Baptist Convention passed resolutions in 1971 and 1974 expressing support for liberalized abortion law, and an editorial in their news agency praised the passage of Roe v Wade, stating that “religious liberty , human equality and justice are advanced by the Supreme Court. abortion decision. As Governor of California, Ronald Reagan passed the nation’s most liberal abortion law in 1967. Conservative icon Barry Goldwater also supported liberalizing abortion law, at least early in his career. career, and his wife Peggy was co-founder of Planned Parenthood in Arizona.

Yet abortion turned out to be the essential unifying issue for two fundamentally political reasons. First, he brought together conservative Catholics who provided much of the movement’s intellectual direction with conservative Protestants and evangelicals. Second, by linking abortion to the perceived social ills of the time—the sexual revolution, the civil rights movement, and women’s liberation—the issue became a focal point for concerns about social change rising from below. .

Over time, pro-choice voices were purged from the Republican Party. In her 2016 book, How the Republican Party Became Pro-Life, Phyllis Schlafly details the tremendous effort it took, over several decades, to force the Republican Party to change its mind on the issue. What his book and the story show is that the “pro-life religion” we see today, crossing the denominational boundaries of the political right, is a modern creation.

US religious leader Reverend Jerry Falwell speaks at Higher Ground Baptist Church in Kingsport, Tennessee (Photo by Kenneth Murray/Photo Researchers History/Getty Images)
Jerry Falwell speaks at the Higher Ground Baptist Church in Kingsport, Tennessee, in 1984. Photograph: Getty Images

Over the past few decades, the religious right has invested several hundred million dollars in developing a complex and coordinated infrastructure, features of which include right-wing political groups, networking organizations, data initiatives, and media. . An essential element of this infrastructure is its sophisticated legal sphere.

The leaders of the movement understood very well that if you can capture the courts, you can change society. Major organizations include the Alliance Defending Freedom, which has been implicated in many recent cases aimed at undermining the principle of separation of church and state; First Freedom; Becket, formerly known as the Becket Fund for Religious Liberty; and the Federalist Society, a networking and support organization for right-wing jurists and their allies whose leader, Leonard Leo, funneled hundreds of millions of dollars to a network of affiliated organizations. This infrastructure has created a pipeline to funnel ideologues into important judicial positions at the state and federal levels. According to Sen. Sheldon Whitehouse, nearly 90% of Trump’s appeals court nominees were or are members of the Federalist Society, and the six conservative Supreme Court justices are current or former members.

The right-wing legal movement has spent decades establishing a new regime in which “religious freedom” is reframed as an exemption from the law, enjoyed by a certain privileged class of religion. LGBT advocacy groups fear the Supreme Court’s willingness in the next session to hear the case of a Colorado website designer who wants to deny services to same-sex couples could be a crucial step to overturn a wide range of anti-discrimination laws that protect LGBT Americans as well as women, members of minority religious groups and others.

Abortion rights supporters at a rally in New York in May.
Abortion rights supporters at a rally in New York in May. Photography: Stephanie Keith/Getty Images

The legal powers of the Christian right have also recognized that their efforts can be turned into a gravy boat of public money. It’s one of the reasons why a recent Supreme Court decision, which ruled that Maine must fund religious schools as part of a state tuition program, was predicted by observers of this movement. This decision obliges the State to finance religious schools, however discriminatory their practices and sectarian their teachings. “This court continues to dismantle the wall of separation between church and state,” Judge Sonia Sotomayor wrote in her dissent.

This Supreme Court has already made clear how quickly our Christian nationalist legal system will change the law to fit this vision of a society run by a reactionary elite, a society with a preferred religion and a prescribed code of sexual behavior, all backed by the coercive power of the state. The idea that they will stop by overthrowing Roe v Wade is an illusion.


Caption Care creates echo access in partnership with Portamedic’s national mobile clinician network to improve heart health and reduce the cost of care

BRISBANE, CA., June 21, 2022 /PRNewswire/ — Caption Health, the leader in AI that enables early disease detection, today unveiled Caption Care™: America’s first in-home cardiac wellness assessment and low-cost echo service. Through a partnership with Portamedic, Inc., one of America’s largest providers of home medical services, mobile technicians across the country will use the Caption AI platform to perform cardiac ultrasounds from the comfort of patients’ homes and in other hands-on environments, to aid in diagnosis and detection before conditions like heart failure become difficult to treat.

“We are changing the approach to the world’s leading cause of death, especially for the underserved. Better assessment of cardiovascular and heart failure risk begins with creating affordable access to basic imaging of the heart. We have partnered with Portamedic and launched Caption Care to bring the most advanced AI-based technology into the homes of everyday Americans, to urgently address the growing risk¹ of heart disease,” said Steve Cashman, CEO of Caption Health. “Given current heart failure guidelines and existing CMS payment models, Medicare Advantage plans will now have a scalable service to help them assess and manage the cardiovascular health of their millions of at-risk members.”

Caption Care offers healthcare providers, payers, and value-based care organizations the ability to have greater reach in their communities by covering the last mile of ultrasound access for members. There is a large and growing need for diagnostic quality ultrasound at the point of care, not only for people with symptoms, but also to guide those at risk of developing heart disease towards early interventions and improving outcomes. Caption Care solves this problem with convenient, cost-effective, large-scale cardiac ultrasound to identify heart disease earlier, help prevent avoidable hospitalizations and support improved outcomes.

Cardiac ultrasounds are the primary tool used to help identify heart failure, the most common diagnosis in the United States for hospitalized patients over the age of 65². It contributes to millions of deaths worldwide every year, but early symptoms like fatigue or shortness of breath are often mistaken for normal signs of aging. Result: A study showed that 38% of new patients with heart failure are diagnosed in acute care settings, even though 46% of these patients had potential symptoms six months before diagnosis, when an intervention would have had greater impact on slowing disease progression³. Doctors call heart failure ‘the silent killer’ because it’s so easy to ignore symptoms until it’s too late, and it’s remained one of the leading causes of death nationwide. , with cases on the rise following the COVID pandemic.

“Portamedic has been a leader in mobile home services for 50 years through a network of more than 4,000 technicians and 100 field offices in all 50 states, giving us reliable access to hundreds of thousands of homes each year. Through our participation in Caption Care, we can now play a proactive role in addressing the greatest public health threat facing this country, and we are excited to take on the challenge,” said Jim Fritz, President and Chief Operating Officer of Portamedic. “As healthcare increasingly moves from the hospital to the home, Caption Health and Portamedic are well positioned with our industry-leading capabilities to bring ultrasound to people in the most comfortable and practice.

Caption Health is a sponsor of AHIP. For more information:

About subtitle health

Caption Health is the leader in AI providing access to cardiac ultrasound for early disease detection – when the potential for impact is greatest. The Company’s Caption Care services provide healthcare providers, payers and value-driven care organizations with convenient and cost-effective echoes for their members, leveraging its Caption AI technology platform. In 2021, Caption Health was recognized as one of TIME’s Top 100 Inventions and winner of Fast Company’s Next Big Things in Tech for health award. Caption Health’s platform is used in leading hospitals, clinics, and physician organizations, and is cited in several peer-reviewed journals, including JAMA Cardiology and Journal of the American Society of Echocardiography. For more information, visit

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  1. Sidick, S.M.. et al. The risk of heart disease skyrockets after COVID – even with a mild case (Nature)
  2. Emory Healthcare, Heart Failure Statistics, 2022
  3. Sandhu, A. et al. (2021). Disparity in the diagnosis of incident heart failure. (Circulation: heart failure)

SOURCE Legend Health

Insufficient standard of care treatments to improve quality of life for patients with multiple myeloma Sun, 19 Jun 2022 14:56:18 +0000 Patients with multiple myeloma frequently relapse and experience deterioration in their quality of life, according to results from the LocoMmotion study, which also reported that specific patient and disease characteristics are associated with poor efficacy outcomes .

Based on LocoMmotion study results presented at the American Society of Clinical Oncology Annual Meeting in early June 2022.

Specific patient and disease characteristics have also been associated with poor outcomes.

Despite advances in MM therapy, most patients relapse after treatment with standard agents, with each additional relapse and line of treatment leading to deterioration in patients’ HRQoL. The authors suggest that this is an area of ​​urgent clinical need to consider in addressing patient quality of life and planning treatment strategies.

The LocoMMotion study is considered the first prospective, multinational, real-life efficacy and safety study of SOC in heavily pretreated, triple-class exposed patients with relapsed/refractory MM.

The study was conducted at 76 sites in the United States, Belgium, France, Germany, Italy, the Netherlands, Poland, Russia, Spain and the United Kingdom.

In a poster, efficacy outcomes, including overall survival, progression-free survival (PFS), overall response rate (ORR), and duration of response (DOR), were assessed in subgroups of MM patients treated with SOC therapies between August 2019 and October 2020.1

Subgroups were based on treatment history, baseline, or disease characteristics.

During the follow-up period, 248 patients were recruited and treated with a median of 4 cycles of SOC therapy.

Triple-class and penta-drug refractory, poor renal function, presence of extramedullary plasmacytomas, elevated lactate dehydrogenase, International Staging System stage II-III, bone marrow plasma cells ≥ 60%, high-risk cytogenetics and Eastern Cooperative Oncology Group performance ≥ 1 were all associated with generally worse outcomes, compared to patients who did not have these characteristics.

However, patients who were refractory to non-triple class therapy had longer median PFS than patients refractory to triple class therapy. The ORR in all subgroups was 31.5% and the median DOR was 7.7 months.

Age and number of previous treatment lines did not impact efficacy results.

These results show that specific patient and disease characteristics are associated with poor outcomes, which “should be considered when planning treatment strategies for this patient population, including bridging therapy for many patients.” novel treatments such as chimeric antigen-receptor T-cells,” the authors concluded.

The second poster assessed symptoms, functioning, and overall HRQoL using patient-reported outcome (PRO) questionnaires.2 Average questionnaire completion was approximately 78% during SOC treatment and approximately 71% during follow-up.

Of the patients who completed the questionnaires during SOC treatment, most did not achieve significant improvement in PRO scores.

The study found that 62% of patients had no significant improvement in pain symptoms during the first 3 months of treatment, and 54% had no improvement throughout treatment.

Limited gains in HRQOL from baseline during SOC treatment were found, mostly worsening during subsequent treatment.

An association between depth of response and HRQOL was observed, with patients who achieved a very good partial response or better with SOC treatments (12.9%) having significantly better improvements in HRQoL.

The study authors suggest focusing on therapies that can help patients achieve profound responses and delay disease progression, as they are associated with improved HRQoL.

“These data show that existing standard-of-care treatments do not significantly improve health-related quality of life, particularly due to lack of response, highlighting the urgent need for effective therapies that can positively impact patients’ health-related quality of life,” said Michel Delforge, MD, PhD, of the University Hospital of Leuven in Belgium, during his presentation at ASCO.


1. Einsele H, Moreau P, De Stefano V, et al. Subgroup analyzes in patients with relapsed/refractory multiple myeloma (RRMM) receiving the actual current standard of care (SOC) in the LocoMMotion study. Presented at: ASCO Annual Meeting; June 3-8, 2022; Chicago, Ill. Poster 8031.

2. Delforge M, Moreau P, Einsele H, et al. Health-related quality of life (HRQoL) in patients with relapsed/refractory multiple myeloma (RRMM) receiving the actual current standard of care (SOC) in the LocoMmotion study. Presented at: ASCO Annual Meeting; June 3-8, 2022; Chicago, Ill. Poster 8030.

Study reveals how lack of technology can impact food insecurity Fri, 17 Jun 2022 21:35:00 +0000

According to Professor Di Fang of the University of Arkansas, the psychological effects of food insecurity can be detrimental. People who are food insecure have a 257% higher risk of anxiety and a 253% higher risk of depression, via BMC Public Health. Along with this, the University of Texas study also concluded that lack of access to technology during the COVID-19 pandemic exacerbated lower mental wellbeing due to social disconnection during the period. exceptionally prolonged isolation from the pandemic.

Another study led by Rachel F. McCloud of the Center for Community-Based Research at the Dana-Farber Cancer Institute in Boston found similar results. The research team monitored the online activities and technological effectiveness of a sample of users from lower socioeconomic backgrounds (via the Journal of the American Medical Informatics Association). Like the University of Texas study, McCloud’s study found that the impacts of lack of technology also extend to poorer urban communities. Due to internet connectivity issues and a lower average technology literacy, people trying to access healthcare information via the internet have been at a significant disadvantage compared to their tech-savvy peers with access to a better quality equipment with fewer problems and subsequent setbacks.

The study concluded that “communication inequalities worsen health disparities” because different communities have access to crucial resources and other communities do not. During the pandemic, in the United States, socioeconomic demographics determined the quality of health care available to a person.

Temple experts remain committed to anti-racism work ahead of June 16, 2022 Wed, 15 Jun 2022 21:01:41 +0000

Juneteenth often serves as a time to discuss racism and how it continues to affect American society. This year, the holiday also almost aligns with the second anniversary of the start of the Black Lives Matter protests in the summer of 2020. The murders of Breonna Taylor, Ahmaud Arbery and George Floyd, and the protests that followed served as catalysts for another great American confrontation with its racist past.

Timothy Welbeck, acting director of the Temple’s Center for Anti-racism Research, explained why the events of summer 2020 had such profound effects on Americans.

“By the time we reached May 25, 2020, there was already a sense of turmoil,” Welbeck said. “The name of Breonna Taylor was starting to spread. People knew the story of Ahmaud Arbery and the advocacy around him. Then video began circulating of Derek Chauvin kneeling on George Floyd’s neck for nine minutes and 29 seconds, and in many ways crystallized many of the arguments made around the reduction in police presence.

“In June 2020, we had protests in all 50 states,” he continued. “An estimated 15 million to 26 million people in the United States participated in these protests, and that’s what started to signal that this time was different in terms of the level of attention paid to a particular incident.”

Some of the reactions that rocked the country following the protests have been labeled by scholars as racial calculus. These reactions include conversations about police reform, the establishment of the Juneteenth as a federal holiday and its corresponding increased respect by corporations, and a greater willingness among Americans to educate themselves on the subject of race.

“Books like Stamped from the start, white fragility and How to be an anti-racist quickly became international bestsellers, and especially in the US they were starting to gain popularity,” Welbeck said. “We also started to see schools expressing at least one value in anti-racism work, education, curriculum – things of that nature.”

More recently, however, Welbeck has paid attention to a series of coordinated efforts to undo the progress and momentum achieved by racial reckoning. Some have called these efforts a “countdown,” and Welbeck and his colleague Gregory Urwin, a history professor at the College of Liberal Arts, have found that efforts to immediately undo racial progress are an American trademark.

“Every meaningful effort toward racial equality in the United States has been met with some kind of coordinated backlash,” Welbeck said. “In particular, the end of slavery and reconstruction are immediately followed by the era of Jim Crow, the black codes and the era of lynching. This post-Civil Rights era was followed by an increased sense of trying to forestall desegregation efforts. We’ve seen attempts to stifle the era of affirmative action, things like that.

A recent example of this coordinated response centers on the topic of critical race theory (CRT), which Welbeck says has been used to try to keep productive conversations about race out of American classrooms.

“This summer just before the start of the 2020 school year, we saw reports literally from across the country of parents screaming passionately about CRT. “Don’t bring it to our schools. It’s racism against white people. Don’t indoctrinate our children,” Welbeck said.

“It’s a very coordinated and deliberate campaign that’s being funded and organized to try to disarm any kind of assessment of racial inequality in the United States, which is why if you look at some of the laws in the 26 states that have declared having banned critical race theory, they don’t actually ban critical race theory, but they ban terms like diversity, equity and inclusion,” he continued. use of words like oppression.”

Confronting our nation’s racist history is something Urwin has been committed to doing throughout his career in history. In doing so, he faced attempts to disarm his own work in a reaction similar to the “not-counting” spoken of by Welbeck and other scholars.

“Like Martin Luther King Jr., I thought the arc of the universe inevitably bent toward justice,” Urwin said as he spoke of growing up watching racial protests, witnessing the passing of laws such as the Civil Rights Act of 1964 and voting rights. Act of 1965 and finally the election of a black president, Barack Obama. “But, you know, there was an attempt to roll back those gains.”

Gregory Urwin has been involved in projects like the feature film Glory and the recent History Channel special Black Patriots: Civil War Heroes for his expertise in military history. (Courtesy of Grégory Urwin)

Urwin has been called a “heritage violator” by sons of Confederate veterans for his work exposing war crimes committed by Confederate soldiers against wounded and captured members of United States colored troops.

“There are people who, either out of fear or for some other reason, try to erase the progress made by African Americans and other minorities. Many of these people have led grassroots campaigns not only to take the control of state legislatures, but also local school boards, so that you can be accused of teaching critical race theory, whatever it is, if you say that slavery was the most important cause of the civil war,” Urwin said. “But it has certainly inspired me to redouble my efforts in the type of work that I do, and I feel like other colleagues who work at the intersection of racial and military history they feel the same thing.”

Over the past decade, Urwin has refocused his work on African Americans who sought freedom during the American Revolution by aligning himself with the British. He is currently working on a book on the subject, titled When freedom wore a red coat.

Urwin also recently helped produce the permanent exhibit at the Museum of the American Revolution in Philadelphia titled find freedomwhich tells the true story of five African Americans involved in the Revolution, four of whom sought freedom by joining the British.

“When inner-city school groups come to the museum and see this, the kids are thrilled, because these are people who look like them,” Urwin said. “The African Americans who joined the British were trying to do what other Americans wanted to do, and that was to enjoy the fruits of freedom. So it makes those kids feel like they’re part of the whole of American history, and I hope it encourages them to look into their own family histories and find other people they can relate to.

Welbeck says he saw a cooling in energy that emerged in the wake of the 2020 protests, but experts like him and Urwin remained committed to their work. Urwin hopes to have When freedom wore a red coat published within five years, while Welbeck prepares the opening of the Center for Research on Anti-Racism.

“Even when it’s not the topic of the day, there still needs to be people committed to anti-racism work and equality and equity work in our country,” Welbeck said. “Temple’s Center for Anti-Racism Research is a great example. It was during this period that we had a racial calculation. We are due to have our grand opening in a few months, so there is a commitment from the university to this work.

Letters: Foregoing student loans makes sense; COFA citizens suffer the effects of nuclear testing; How much water does Waikiki consume? Sun, 12 Jun 2022 10:05:42 +0000 Mahalo for supporting Honolulu Star-Advertiser. Enjoy this free story!

Van Hollen and Cardin join colleagues in presenting a resolution recognizing June as LGBTQ Pride Month Fri, 10 Jun 2022 21:15:41 +0000

June 10, 2022

U.S. Senators Chris Van Hollen (D-Md.), Ben Cardin (D-Md.), Sherrod Brown (D-Ohio), Dianne Feinstein (D-Calif.), and Tina Smith (D-Minn.) presented a Senate resolution recognizing June as LGBTQ Pride Month. The senators’ resolution highlights the contributions LGBTQ people have made to American society, notes several milestones in the fight for equal treatment for LGBTQ Americans, and resolves to continue efforts to achieve full equality for LGBTQ people. The resolution also acknowledges how the U.S. Supreme Court’s pending bill to strike down Roe vs. Wade could potentially undermine and erode other constitutional rights also based on privacy, including the right for same-sex couples to marry or engage in consensual relationships without risk of criminal prosecution.

As we mark the start of Pride Month, we celebrate the progress our nation has made, but recognize that the fight is far from over as many LGBTQ+ Americans still do not enjoy equal protections under the law. », said Senator Van Hollen. “I will continue to work to fight for the rights of all members of the LGBTQ+ community and to pass the Equality Act to ensure that no American is discriminated against because of who they are. It will bring us closer to defending the ideals on which our country was founded – freedom and justice for all.

“We dedicate the month of June to celebrating the triumphs of the LGBTQ+ community while recognizing their struggles and the work that remains to be done. In this Pride month, it is essential that we stand together to elevate and support LGBTQ+ voices, especially our children, at a time when local and state legislatures are attacking their rights. No one should be afraid to be true and authentic themselves,” said Senator Cardin.

“More than 50 years ago, the Stonewall Uprising, led largely by trans women of color, brought national attention to the ongoing movement for justice that endures today in Ohio and throughout all the countries”, said Senator Brown. “This Pride Month – and throughout the year – we recommit to gender equality and social, economic and racial justice, and to uphold marriage equality as a constitutional right. guaranteed by the Supreme Court seven years ago.”

“Everyone has the right to live their authentic life without discrimination or hatred. I am proud of the tremendous progress made in the fight for justice, equality and inclusion,” said Senator Feinstein. “This Pride Month, as we celebrate this progress, let’s also recognize that we still have work to do and continue to push for true equality.”

“This month, and throughout the year, we celebrate, recognize and uplift the LGBTQ+ community,” said Senator Smith. “The freedom to live and love openly is fundamental. This Pride month, we recognize the courage and achievements of those who have been on the front lines of the LGBTQ movement and recommit ourselves to the fight for justice. and equality. I’m proud to help lead this resolution.”

In 2021, Senate Democrats reintroduced the Equality Act, legislation to ensure that civil rights laws prohibit discrimination based on sexual orientation and gender identity. The Equality Act would unequivocally prohibit discrimination in a host of areas, including employment, housing, public accommodations, jury service, access to credit, federal financial aid, and education.

Along with Senators Van Hollen, Cardin, Brown, Feinstein and Smith, the resolution was co-sponsored by Senators Jeff Merkley (D-Ore.), Richard Blumenthal (D-Conn.), Ed Markey (D-Mass.), Maggie Hassan (DN.H.), Brian Schatz (D-Hawaii), Angus King (I-Maine), Tom Carper (D-Del.), Maria Cantwell (D-Wash.), Chris Murphy (D-Conn.) , Sheldon Whitehouse (DR.I.), Bob Casey (D-Pa.), Elizabeth Warren (D-Mass.), Richard Durbin (D-Ill.), Tammy Duckworth (D-Ill.), Kirsten Gillibrand (DN .Y.), Mazie Hirono (D-Hawaii), Tammy Baldwin (D-Wis.), Bernie Sanders (I-Vt.), Tim Kaine (D-Va.), Jacky Rosen (D-Nev.), Catherine Cortez Masto (D-Nev.), Amy Klobuchar (D-Minn.), Alex Padilla (D-Calif.), Joe Manchin (DW.Va.), Cory Booker (DN.J.), Patrick Leahy (D- Vt.), Chris Coons (D-Del.), Jack Reed (DR.I.), Reverend Raphael Warnock (D-Ga.), Debbie Stabenow (D-Mich.), Mark Warner (D-Va.) , Martin Heinrich (DN.M.), John Hickenlooper (D-Colo.), Bob Menendez (DN.J.), Jeanne Shaheen (DN.H.), Mark Kelly (D-Arizona) , Ron Wyden (D-Ore.), Ben Ray Luján (DN.M.), Patty Murray (D-Wash.), Kyrsten Sinema (D-Arizona), Gary Peters (D-Mich.), Michael Bennet (D -Colo .), Jon Tester (D-Mont.), John Ossoff (D-Ga.) and Chuck Schumer (DN.Y.).

The full text of the resolution is available here.

This year’s Pride Resolution has been endorsed by the Human Rights Campaign (HRC).

Small rectal cancer drug trial sees tumors disappear in 100% of patients Wed, 08 Jun 2022 23:58:00 +0000
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Small drug trial has seismic impact in oncology world: After six months of experimental treatment, tumors disappeared in 14 patients diagnosed with early-stage rectal cancer who completed study at the time of its publication.

Colorectal cancer researchers hail the study, published Sunday in the New England Journal of Medicine, as a groundbreaking development that could also lead to new treatments for other cancers.

“I don’t think anyone has seen this before, where every patient has seen their tumor disappear,” said Andrea Cercek, an oncologist at Memorial Sloan Kettering Cancer Center in New York and lead author of the study.

The patients all shared the same genetic instability in their rectal cancer and had not yet undergone treatment. Each received nine doses of intravenous dostarlimab, a relatively new drug designed to block a cancer cell-specific protein that, when expressed, can cause the immune system to withhold its anti-cancer response.

After six months, scans that once showed lumpy, discolored tumors instead revealed smooth, pink tissue. No trace of cancer was detected in scans, biopsies or physical exams.

“All 14 patients? The odds are extremely low and really unknown in oncology,” Cercek said.

The results were so successful that none of the 14 patients who completed the trial needed the planned follow-up treatment of chemo-radiation or surgery, and none had significant complications from the drug. . Four other patients in the trial are still on treatment but are showing the same promising results so far.

Sascha Roth, the first patient to enter the experimental study in late 2019, knows firsthand how important the results are, but said that since the news broke on Sunday, she and her family are beginning to understand. the wider impact.

“My cousin from Brussels said it was in the paper there,” Roth said Tuesday. “It affects everyone.”

The results point to a promising option for the treatment of rectal cancer, which can often leave patients with life-changing effects.

Although rectal cancer is highly survivable when treated in its early stages, the most effective traditional treatments of radiation, chemotherapy, and surgery can also leave patients with permanent bowel and bladder dysfunction. sexual dysfunction and infertility. For younger women, the treatment may cause scarring of the uterus, rendering them unable to carry a pregnancy; other patients with low rectal tumors must permanently use a colostomy bag after surgery.

The study has caveats: The sample size of patients, while diverse in terms of age, race and ethnicity, was small. And even the first patients in the trial still have several years of observation to make sure the tumors haven’t reappeared or metastasized elsewhere in the body. The results also apply only to those who carry a specific abnormality in their rectal cancer known as mismatch repair deficit, which prevents the body’s function from normalizing or “repairing” abnormalities when cells divide and instead lead to mutations. The deficiency occurs in about 5-10% of all rectal cancer patients and tends to be resistant to chemotherapy.

“We’re definitely seeing an influx of people calling in saying, ‘Is this drug for me? “said Cercek. “It’s a very emotional reaction of, ‘Oh my God, they had cancer and now look at them.’ ”

Scott Gottlieb, Commissioner of the U.S. Food and Drug Administration, details the steps the U.S. government is taking to approve innovative new cancer drugs, therapies, and clinical trials. (Video: Washington Post Live)

David Ryan, director of clinical oncology at Massachusetts General Hospital, said the findings were a game-changer for cancer patients with a mismatch repair deficit. The study was sponsored by biotech company Tesaro – which was acquired by GlaxoSmithKline when the first patient started treatment in 2019.

“It’s a really big deal,” said Ryan, who wasn’t involved in the study. “It’s going to be really hard not to think about it for the next patient that comes through the door: ‘Should I do chemo and radiation, or should I do this immunotherapy?’ ”

Ryan said trial participants have been and will continue to be closely monitored by a team of specialists who will be able to watch for any recurrence or spread of the tumor and intervene quickly with treatment if needed. He said the need could be a challenge for patients who don’t live near a place where they can easily and regularly access specialist care.

“We are concerned that if recurrences occur they should be caught as soon as possible to give people the best chance,” he said.

But Ryan and Cercek said separately that the trial results raise the specter that anyone with a mismatch repair deficit in other types of tumors, such as those of the pancreas, stomach or bladder , could be effectively treated with the same drug from Cercek’s study.

For Ryan, the study also reinforces the importance for cancer patients to know their mismatch repair status.

“We always knew that, but we didn’t know that these were the types of tumors that respond like gangbusters to immunotherapy and tumors melt away like butter with treatment,” he said. .

Cercek presented the paper Sunday at the American Society of Clinical Oncology annual meeting in Chicago. She hadn’t even finished her 10-minute presentation when the room erupted in applause. Gasps and tears ran through the audience as bold underlined white letters appeared on a blue screen with the key finding of his study: “100% COMPLETE clinical response in the first 14 consecutive patients”.

Simply put, it was like kicking a football after a touchdown.

Roth, now 41, feels equally triumphant. She described her journey through the trial as “bizarre”.

“All the stars lined up perfectly, which allowed me to do this test,” she said. “If I had done just one chemo infusion, it would have disqualified me.”

Roth, who lives in Bethesda, Maryland, and runs a furniture store, was diagnosed in September 2019 when she was 38. She had had rectal bleeding and attributed it to anti-inflammatories she had been taking due to her active lifestyle, which included occasional bicycle accidents and football collisions.

“I thought they were going to tell me I had a gluten allergy,” Roth said. “I certainly wasn’t expecting a cancer diagnosis.”

She spoke to a friend who had been diagnosed with colorectal cancer a year and a half earlier who advised her: Memorial Sloane Kettering or bust. Three days before she was due to start chemotherapy in the Washington area, she met an MSK doctor who she recalled “throwing down the gauntlet” in the exam room.

“He said, ‘One, you’re not a candidate for surgery because of where the cancer is'” and also informed her that chemotherapy – usually standard care – would not be a an effective option given that she had a cancerous abnormality that tends to be resistant to this treatment.

The doctor was almost certain that she was a “Lynch” patient, or someone with an inherited cancer syndrome associated with abnormalities. Roth’s doctor introduced her to Cercek, and she soon became the trial’s first patient.

Roth would have to wait another two months for FDA approval before he could start the experimental treatment.

“In my mind, with each passing day, I’m wide-eyed and insane,” she said of fearing her cancer could worsen from stage 3 to stage 4 while waiting. . “But I was reassured that cancer does not develop overnight.”

Roth was closely watched to make sure it was safe to wait for her treatment and keep her in the trial. She started the experimental therapy in December 2019. After her first infusion, she went on vacation to Florida and reported experiencing no adverse side effects. She even continued to run.

Halfway through the trial, Roth’s tumor was visibly shrinking. After six months, when Roth switched to chemotherapy, she received a call late Friday night from Cercek telling her to cancel her move to New York. The researchers would adjust the trial; chemo – as well as radiation or surgery – would no longer be necessary, at least for now.

Roth’s family jokes that she is a “unicorn”, a living example of a medical miracle. What Roth feels is gratitude — for the doctors and nurses, and for those who encouraged her to stand up for herself and seek a second opinion.

She is also grateful for scientific advances, given the prevalence of cancer in her family. Roth’s father died of brain cancer in 1999, and his mother is currently living “the last days of her life” battling cancer. Thanks to innovations in the field, she feels optimistic about her own future.

“I feel a universal sense of gratitude – but also of hope for others,” she said. “Hope for all cancers.”

]]> US sees heightened extremist threat heading into midterms Tue, 07 Jun 2022 15:13:00 +0000 A looming Supreme Court ruling on abortion, a surge in the number of migrants at the U.S.-Mexico border and midterm elections are potential triggers for extremist violence in the next six months, the Department said Tuesday. internal security. Supreme Court on Roe v. Wade’s United States was already in a “heightened threat environment,” and these factors could make the situation worse, the DHS said in the National Terrorism Advisory System’s latest bulletin. “In the coming months, we expect the threat environment to become more dynamic as multiple high-profile events could be exploited to justify acts of violence against a range of possible targets,” the DHS said on the international terrorism that characterized the agency after its creation after the attacks of September 11, 2001. Indeed, threats from abroad are only passing men in this bulletin. celebrated the January clash at a synagogue in Colleyville, Texas, and says the Islamic State group has called on its supporters to carry out attacks in the United States in revenge for the killing of the group’s leader and spokesperson. also warns that China, Russia, Iran and other countries seek to foment divisions within the United States weaken the country and its position in the world.In part, they do so by amplifying conspiracy theories and the false reports that proliferate in American society. Domestic violent extremists, however, pose the most pressing and potentially violent threat, the agency said, citing, for example, the racist attack in which a white gunman killed 10 black people at a supermarket in Buffalo, New York, in May. A senior DHS official, speaking to reporters ahead of the bulletin’s release, said he described the situation as “dynamic” because authorities are seeing a greater variety of people motivated by a wider range of grievances and challenges. incidents than in the past. The upcoming Supreme Court decision, which could overturn Roe v. Wade, could lead to violence from extremist supporters or opponents of abortion rights depending on t The outcome, the official said, speaking on condition of anonymity to discuss some factors that went into the preparation of the newsletter. has been used since the start of the coronavirus pandemic to prevent people from seeking asylum at the Southwest border, DHS said. The agency and FBI are working with state and local law enforcement to raise awareness of the threat, and DHS has increased grant funding to local governments and religious organizations to improve security, the Secretary of State said. Homeland Security, Alejandro N. Mayorkas, in a statement released with the bulletin.

A looming Supreme Court ruling on abortion, a surge in migrants at the U.S.-Mexico border and midterm elections are potential triggers for extremist violence in the next six months, the Department of Health said Tuesday. Homeland security.

Related video above: Get the Facts: Supreme Court on Roe v. wade

The United States was already in a “heightened threat environment,” and these factors could worsen the situation, the DHS said in the latest bulletin from the National Terrorism Advisory System.

“In the coming months, we expect the threat environment to become more dynamic as multiple high-profile events could be leveraged to justify acts of violence against a range of possible targets,” DHS said.

It’s Homeland Security’s latest attempt to draw attention to the threat posed by domestic violent extremism, a shift from the international terrorism alerts that were a feature of the agency after it was created after the attacks of September 11, 2001.

Indeed, threats from abroad are only mentioned in passing in this bulletin. He notes that al-Qaeda supporters celebrated the January clash at a synagogue in Colleyville, Texas. And he mentions that the Islamic State group has called on its supporters to carry out attacks in the United States to avenge the murder of the group’s leader and spokesman.

DHS also warns that China, Russia, Iran and other countries seek to foment divisions within the United States to weaken the country and its standing in the world. In part, they do this by amplifying the conspiracy theories and false reports that proliferate in American society.

Domestic violent extremists, however, pose the most pressing and potentially violent threat, the agency said, citing, for example, the racist attack in which a white gunman killed 10 black people at a Buffalo supermarket, New York, in May.

The bulletin, which is due to expire Nov. 30, said calls for violence by domestic extremists directed against democratic institutions, candidates and election workers are likely to increase throughout the fall.

A senior DHS official, speaking to reporters ahead of the bulletin’s release, said he described the situation as “dynamic” because authorities are seeing a greater variety of people motivated by a wider range of grievances and challenges. incidents than in the past.

The upcoming Supreme Court decision, which could overturn Roe v. Wade, could lead to violence from extremist supporters or abortion rights opponents depending on the outcome, the official said, speaking on condition of anonymity to discuss some factors. in the preparation of the newsletter.

Racial extremists may be motivated by immigration enforcement or if the government continues to rely on Title 42, the public health order that has been used since the start of the coronavirus pandemic to prevent people seeking asylum at the southwest border, DHS said.

The agency and FBI are working with state and local law enforcement to raise awareness of the threat, and DHS has increased grant funding to local governments and religious organizations to improve security, the Secretary of State said. Homeland Security, Alejandro N. Mayorkas, in a statement released with the bulletin.

The American Cancer Society urges people to test for cancer | Company Sun, 05 Jun 2022 23:13:22 +0000