AACC Releases Guidelines for Improving Care for Acute Kidney Injury Through Clinical Laboratory Tests


WASHINGTON, May 11, 2021 / PRNewswire / – Over the past decade, experts’ understanding of acute kidney injury (AKI) screening has evolved dramatically, but current medical practice has yet to catch up with the latest research in this area. The AACC has therefore released a new AKI guidance document that provides laboratories and other healthcare professionals with the latest best practices in diagnosing and managing this potentially fatal disease.

Read the guidance document here: http://www.aacc.org/science-and-research/aacc-academy-guidance/laboratory-investigation-of-acute-kidney-injury

AKI, which is defined as a sudden episode of kidney injury or failure, is a condition that affects up to 15% of hospital patients and can lead to serious complications or death. A wide range of causes can trigger AKI – from major surgeries to drugs that affect kidney function – and its symptoms can vary depending on the underlying cause, making it a difficult condition to diagnose and treat. It is therefore essential that clinical laboratory professionals and clinicians know what the right tools are for diagnosing AKI. However, current approaches to detecting this condition differ widely in the medical community due to factors such as the inconsistent integration of new AKI findings into clinical practice. This has led to considerable disparities in the identification and management of AKI across the world, and underscores the need for a consistent set of best practices for testing this condition.

To improve patient care and AKI outcomes, a multidisciplinary group of clinical laboratory experts and nephrologists formed by the AACC academy has developed evidence-based guidance on laboratory testing for the ‘AKI. One of the guide’s main recommendations addresses a gap in AKI’s current diagnostic criteria with the creatinine test (the primary test for this condition), which was established by the 2012 Kidney Disease Guidelines. Improving Global Results (KDIGO). Recent studies have linked the use of the KDIGO diagnostic criteria with a high rate of false positive AKI diagnoses. To address this, the AACC guidelines suggest using new diagnostic cutoffs, known as the AACC AKI 20/20 criteria, to determine if a patient has AKI with a creatinine test. The use of these new criteria is supported by strong evidence from a study of 14,912 adult patients.

The AACC guidance document also covers when to test AKI; other good practices for creatinine testing; the usefulness of other tests used to identify the cause of AKI and guide treatment; and the usefulness of new tests for AKI, including a machine learning-based approach to predict the development of this condition in patients.

“Our understanding and the tools used to detect AKI have both evolved since the publication of KDIGO in 2012,” said lead authors of the guide, Drs. Joe M. El-Khoury and Chirag R. Parikh. “The information and opinions provided in this document are intended to shed light on the current state of the field and to generate a healthy debate with clinical organizations which leads to a much needed update of our current investigative practice. AKI. Clinicians and laboratory workers should work together to implement [our findings and recommendations]. “

About AACC
Dedicated to improving health through laboratory medicine, AACC brings together more than 50,000 clinical laboratory professionals, physicians, researchers and business leaders from around the world focused on clinical chemistry, molecular diagnostics, spectrometry mass, translational medicine, laboratory management and others. areas of progress in laboratory science. Since 1948, the AACC has strived to advance the common interests of the field, delivering programs that advance scientific collaboration, knowledge, expertise and innovation. For more information visit www.aacc.org.

Christine DeLong
Senior Manager, Communications and Public Relations
(p) 202.835.8722
[email protected]

Molly polen
Senior Director, Communications and Public Relations
(p) 202.420.7612
(c) 703.598.0472
[email protected]


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